Lamitan
Generic Name
Lamotrigine
Manufacturer
Multiple manufacturers (e.g., Eskayef Pharmaceuticals Ltd. in BD)
Country
Bangladesh (for local brands), UK (originator)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lamitan 50 mg tablet | ৳ 40.00 | ৳ 400.00 |
| lamitan 100 mg tablet | ৳ 75.00 | ৳ 750.00 |
Description
Overview of the medicine
Lamotrigine is an anticonvulsant medication used to treat epilepsy (seizures) and bipolar disorder. It helps to stabilize electrical activity in the brain.
Uses & Indications
Dosage
Adults
Varies significantly based on indication and concomitant medications. Typically starting with 25 mg daily, titrated slowly upwards over several weeks to a usual maintenance dose of 100-400 mg/day.
Elderly
No specific dosage adjustments required unless hepatic or renal impairment is present. Start at lower end of dosing range.
Renal_impairment
Reduced maintenance dosage may be required. Caution advised. Consider using a lower initial dose and slower escalation.
How to Take
Oral administration, with or without food. Chewable/dispersible tablets can be swallowed whole, chewed, or dispersed in a small amount of water.
Mechanism of Action
Lamotrigine stabilizes neuronal membranes by blocking voltage-sensitive sodium channels, thereby inhibiting the release of excitatory neurotransmitters (e.g., glutamate and aspartate).
Pharmacokinetics
Onset
Weeks to achieve steady state and therapeutic effect, especially when titrated slowly.
Excretion
Mainly renal, with about 10% excreted unchanged.
Half life
Approximately 25-33 hours (can be affected by concomitant medications).
Absorption
Rapid and complete absorption after oral administration; peak plasma concentrations reached in 1.4-4.8 hours.
Metabolism
Primarily hepatic glucuronidation to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to lamotrigine or any component of the formulation.
- •Patients with a history of severe dermatological reactions to lamotrigine.
Drug Interactions
Valproate
Significantly increases lamotrigine half-life and plasma levels, requiring dose reduction of lamotrigine.
Rifampicin
Decreases lamotrigine plasma levels.
Oral contraceptives (estrogen-containing)
May decrease lamotrigine levels, leading to loss of seizure control. Requires monitoring and dose adjustment.
Carbamazepine, Phenytoin, Phenobarbital, Primidone
Decrease lamotrigine plasma levels, requiring dose increase of lamotrigine.
Storage
Store below 30°C (86°F) in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nystagmus, ataxia, dizziness, headache, drowsiness, seizures, and coma. No specific antidote; symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk. Higher doses may be needed during pregnancy. Excreted in breast milk, use with caution, monitor infants for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to specific product labeling for exact expiry date)
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA (USA), DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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