Lanozole
Generic Name
Lansoprazole 15 mg capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lanozole 15 mg capsule | ৳ 3.00 | N/A |
Description
Overview of the medicine
Lansoprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It is used to treat and prevent stomach and esophageal problems such as acid reflux, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For duodenal ulcer: 30 mg once daily for 4 weeks. For gastric ulcer and reflux esophagitis: 30 mg once daily for 8 weeks. For H. pylori eradication: 30 mg twice daily for 7-14 days with appropriate antibiotics. For Zollinger-Ellison syndrome: 60 mg once daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution in severely impaired hepatic function. Close monitoring is recommended.
Renal_impairment
No dose adjustment generally required. However, for severe impairment, monitoring is advised.
How to Take
Take capsules orally before food, preferably in the morning. Swallow whole, do not chew or crush. For patients unable to swallow, capsules can be opened and the granules mixed with a small amount of apple juice or soft food.
Mechanism of Action
Lansoprazole is a substituted benzimidazole, which inhibits the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells. By irreversibly blocking the final step in gastric acid secretion, it significantly reduces both basal and stimulated acid production.
Pharmacokinetics
Onset
Acid suppression within 1-2 hours. Full therapeutic effect typically achieved within 2-3 days of daily dosing.
Excretion
Primarily excreted in urine (15-30%) and feces (60-80%) as inactive metabolites.
Half life
Approximately 1.3 to 1.7 hours (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, bioavailability is about 80-90%. Food can delay absorption but does not significantly affect overall efficacy.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to lansoprazole or any component of the formulation
- Concurrent use with atazanavir or nelfinavir due to significant reduction in their plasma concentrations
Drug Interactions
Digoxin
Increased absorption of digoxin due to increased gastric pH, consider dose adjustment.
Warfarin
Potential for increased INR/bleeding risk, close monitoring recommended.
Tacrolimus
Increased tacrolimus plasma concentrations; monitor levels.
Clopidogrel
Possible reduction in antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Methotrexate
May increase methotrexate levels, especially with high-dose therapy; consider temporary PPI discontinuation.
Atazanavir, Nelfinavir
Reduced absorption and efficacy of these antiretrovirals due to increased gastric pH.
Iron Salts, Ketoconazole, Itraconazole
Reduced absorption of drugs requiring an acidic gastric pH for absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms are generally mild and include lethargy, tremor, convulsions. Treatment is symptomatic and supportive. Lansoprazole is not significantly removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excreted in breast milk, so caution is advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to lansoprazole or any component of the formulation
- Concurrent use with atazanavir or nelfinavir due to significant reduction in their plasma concentrations
Drug Interactions
Digoxin
Increased absorption of digoxin due to increased gastric pH, consider dose adjustment.
Warfarin
Potential for increased INR/bleeding risk, close monitoring recommended.
Tacrolimus
Increased tacrolimus plasma concentrations; monitor levels.
Clopidogrel
Possible reduction in antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Methotrexate
May increase methotrexate levels, especially with high-dose therapy; consider temporary PPI discontinuation.
Atazanavir, Nelfinavir
Reduced absorption and efficacy of these antiretrovirals due to increased gastric pH.
Iron Salts, Ketoconazole, Itraconazole
Reduced absorption of drugs requiring an acidic gastric pH for absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms are generally mild and include lethargy, tremor, convulsions. Treatment is symptomatic and supportive. Lansoprazole is not significantly removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excreted in breast milk, so caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on specific manufacturer guidelines.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available; original patent expired
WHO Essential Medicine
YesClinical Trials
Lansoprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Studies have consistently shown superior acid suppression compared to placebo and comparable efficacy to other PPIs for indications like GERD and ulcer healing. Ongoing research continues to explore its long-term safety profile and potential new applications.
Lab Monitoring
- Monitor for signs and symptoms of Clostridium difficile-associated diarrhea with prolonged use.
- Consider checking serum magnesium levels periodically in patients expected to be on long-term therapy, especially with diuretics.
- Monitor for Vitamin B12 deficiency with prolonged use (>3 years).
- Liver function tests in patients with severe hepatic impairment.
Doctor Notes
- Before initiating PPI therapy for gastric ulcer, exclude malignancy.
- Prescribe the lowest effective dose for the shortest duration consistent with the condition being treated.
- Consider monitoring for hypomagnesemia and vitamin B12 deficiency in patients on prolonged PPI therapy, especially if comorbid conditions or other medications increase risk.
- Educate patients on proper administration (swallow whole, before meals) and potential long-term risks.
Patient Guidelines
- Take the capsule whole, do not crush or chew. It should be taken before a meal.
- If you miss a dose, take it as soon as you remember, unless it's nearly time for your next dose.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
- Do not stop taking the medicine abruptly unless advised by your doctor, as symptoms may return.
- Seek immediate medical attention if you experience severe allergic reactions, unexplained weight loss, or persistent vomiting.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Driving Precautions
Lansoprazole generally does not affect the ability to drive or operate machinery. However, some patients may experience side effects such as dizziness or visual disturbances. If these occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods like spicy, fatty, acidic foods, caffeine, and alcohol to help manage symptoms.
- Elevate the head of your bed while sleeping to reduce nighttime acid reflux.
- Maintain a healthy weight and eat smaller, more frequent meals.
- Quit smoking, as it can worsen acid reflux.
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