Medicine Information

Lebac

Name: Lebac
Brand: Lebac

Pediatric Drop (Oral Suspension)125 mg/5 mLAntibacterial (3rd Generation Cephalosporins)ATC: J01DD08

Generic Name

Cefixime 125 mg Pediatric Drop

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lebac 125 mg pediatric drop	৳ 65.19	N/A

Description

Overview of the medicine

Lebac 125 mg Pediatric Drop contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat various bacterial infections in children, including respiratory tract infections, urinary tract infections, and otitis media.

Uses & Indications

Acute otitis media (AOM)

Pharyngitis and tonsillitis

Acute exacerbations of chronic bronchitis

Uncomplicated urinary tract infections (UTIs)

Uncomplicated gonorrhea

Acute bacterial sinusitis

Dosage

Elderly

Dosage adjustment is generally not necessary unless renal function is significantly impaired.

Pediatric

For children 6 months to 12 years: 8 mg/kg/day administered as a single dose or in two divided doses every 12 hours. The usual dose for a child weighing 6.25 kg is 2.5 mL once daily or 1.25 mL every 12 hours.

Renal_impairment

In severe renal impairment (creatinine clearance <30 mL/min), the total daily dose should be reduced by 50%.

How to Take

Lebac Pediatric Drop should be administered orally, with or without food. Shake the bottle well before each use. Use the provided dropper or measuring cup for accurate dosing.

Mechanism of Action

Cefixime works by inhibiting bacterial cell wall synthesis, leading to the lysis and death of bacteria.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 2-6 hours after administration.

Excretion

Primarily excreted unchanged in the urine (about 50%) and bile.

Half life

Plasma half-life is typically 3-4 hours.

Absorption

Approximately 40-50% orally absorbed. Food can delay absorption but does not significantly affect the extent.

Metabolism

Minimal metabolism; a small portion undergoes hepatic metabolism.

Side Effects

Contraindications

Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of serious hypersensitivity reactions to penicillin antibiotics.

Drug Interactions

Warfarin

May increase prothrombin time, monitor INR.

Carbamazepine

May increase carbamazepine levels; monitor drug levels.

Oral Anticoagulants

May enhance anticoagulant effects; monitor coagulation parameters.

Storage

Store the dry powder at room temperature (below 30°C), protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and do not freeze.

Overdose

In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be supportive and symptomatic. Hemodialysis or peritoneal dialysis does not remove Cefixime from the body in significant amounts.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in low concentrations in human milk; caution should be exercised when administered to a nursing mother.

Side Effects

Contraindications

Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of serious hypersensitivity reactions to penicillin antibiotics.

Drug Interactions

Warfarin

May increase prothrombin time, monitor INR.

Carbamazepine

May increase carbamazepine levels; monitor drug levels.

Oral Anticoagulants

May enhance anticoagulant effects; monitor coagulation parameters.

Storage

Store the dry powder at room temperature (below 30°C), protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and do not freeze.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 mL bottle50 mL bottle

Shelf Life

Unreconstituted powder: 2-3 years. Reconstituted suspension: 14 days when stored in a refrigerator.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating a variety of bacterial infections, particularly in pediatric populations.

Lab Monitoring

Regular monitoring of renal function in patients with pre-existing renal impairment or during prolonged high-dose therapy.
Periodic monitoring of complete blood count (CBC) in prolonged therapy.

Doctor Notes

Ensure accurate dosing based on the child's weight to prevent under-dosing or over-dosing.
Advise parents about the importance of completing the full course of antibiotics.
Monitor for signs of allergic reactions, especially in patients with a history of penicillin allergy.

Patient Guidelines

Complete the entire prescribed course of medication, even if symptoms improve.
Do not share this medication with others, even if they have similar symptoms.
Shake the bottle well before each use and use the provided measuring device for accurate dosing.
Store the reconstituted suspension in the refrigerator and discard after 14 days.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Cefixime may cause dizziness in some patients. Patients should be cautioned about operating hazardous machinery or driving until they are reasonably certain that Cefixime does not adversely affect them.