Levomax TS
Generic Name
Levofloxacin
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| levomax ts 15 eye drop | ৳ 130.00 | N/A |
Description
Overview of the medicine
Levofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections including pneumonia, bronchitis, sinusitis, skin and soft tissue infections, and urinary tract infections.
Uses & Indications
Dosage
Adults
Typically 250 mg to 500 mg orally once daily, depending on the type and severity of infection. For some severe infections, 750 mg once daily might be prescribed.
Elderly
Similar to adults, but careful monitoring of renal function is advised, and dose adjustments may be necessary.
Renal_impairment
Dose adjustment is required based on creatinine clearance. For CrCl 20-49 mL/min, 250 mg every 48 hours; for CrCl 10-19 mL/min, 250 mg initial dose then 125 mg every 48 hours.
How to Take
Levomax TS tablets can be taken orally with or without food. It should be swallowed whole with a sufficient amount of liquid. Do not crush or chew.
Mechanism of Action
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Onset of action within 1-2 hours of administration.
Excretion
Primarily excreted unchanged in the urine (approximately 87% within 48 hours).
Half life
Elimination half-life is typically 6-8 hours.
Absorption
Rapid and nearly complete oral absorption; peak plasma concentrations achieved within 1-2 hours. Bioavailability is approximately 99%.
Metabolism
Minimally metabolized in the liver; less than 5% is metabolized.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy
- Children and adolescents during growth period
- Pregnancy and breastfeeding
Drug Interactions
0
Antacids (containing magnesium or aluminum) and sucralfate: Can reduce levofloxacin absorption. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
1
Iron and Zinc supplements: Can reduce absorption. Administer levofloxacin at least 2 hours before or 2 hours after these supplements.
2
NSAIDs: May increase the risk of CNS stimulation and convulsive seizures.
3
Warfarin: May enhance the anticoagulant effects of warfarin, requiring monitoring of INR.
4
Corticosteroids: Increased risk of tendinitis and tendon rupture.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an acute overdose, the stomach should be emptied. The patient should be observed and hydration maintained. ECG monitoring is advised due to the potential for QT prolongation. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, breastfeeding is not recommended during treatment.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy
- Children and adolescents during growth period
- Pregnancy and breastfeeding
Drug Interactions
0
Antacids (containing magnesium or aluminum) and sucralfate: Can reduce levofloxacin absorption. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
1
Iron and Zinc supplements: Can reduce absorption. Administer levofloxacin at least 2 hours before or 2 hours after these supplements.
2
NSAIDs: May increase the risk of CNS stimulation and convulsive seizures.
3
Warfarin: May enhance the anticoagulant effects of warfarin, requiring monitoring of INR.
4
Corticosteroids: Increased risk of tendinitis and tendon rupture.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an acute overdose, the stomach should be emptied. The patient should be observed and hydration maintained. ECG monitoring is advised due to the potential for QT prolongation. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Available in all pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of levofloxacin for its approved indications. Ongoing research explores its role in emerging resistant pathogens and new therapeutic areas.
Lab Monitoring
- Renal function tests (creatinine clearance)
- Blood glucose levels (especially in diabetic patients receiving concomitant hypoglycemic agents)
- ECG monitoring (in patients at risk for QT prolongation)
Doctor Notes
- Emphasize black box warnings to patients, particularly regarding tendon rupture and peripheral neuropathy.
- Adjust dose carefully for patients with renal impairment.
- Counsel patients to avoid concomitant use with multivalent cations (antacids, iron, zinc) and corticosteroids.
- Monitor for signs of C. difficile infection.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Avoid excessive sun exposure and use sunscreen, as fluoroquinolones can cause photosensitivity.
- Report any tendon pain, swelling, or inflammation immediately to your doctor.
- Do not take with antacids or iron/zinc supplements; separate by at least 2 hours.
- Stay well-hydrated during treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Levofloxacin may cause dizziness, lightheadedness, visual disturbances, or confusion, which could impair your ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and lifestyle.
- Avoid direct sunlight or use protective clothing/sunscreen.
- Monitor blood sugar levels if diabetic.
- Report any unusual numbness, tingling, or weakness.
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