Lexopam
Generic Name
Bromazepam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lexopam 3 mg tablet | ৳ 4.50 | ৳ 45.00 |
Description
Overview of the medicine
Lexopam is a brand name for Bromazepam, a benzodiazepine used for the short-term treatment of anxiety, panic attacks, and psychosomatic conditions.
Uses & Indications
Dosage
Adults
Typically 3-18 mg daily in divided doses, adjusted according to individual response.
Elderly
Lower initial doses are recommended, e.g., 1.5-3 mg daily, to minimize adverse effects.
Renal_impairment
Caution is advised; dose reduction may be necessary in severe renal impairment.
How to Take
Administer orally, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Bromazepam enhances the effect of gamma-aminobutyric acid (GABA) at the GABA-A receptors, leading to central nervous system depression, which produces anxiolytic, sedative, muscle relaxant, and anticonvulsant effects.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Mainly excreted in the urine as metabolites.
Half life
10-20 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations occur within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2C19, into inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to bromazepam or other benzodiazepines
- •Severe respiratory insufficiency
- •Severe hepatic insufficiency
- •Sleep apnea syndrome
- •Myasthenia gravis
- •Acute narrow-angle glaucoma
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Alcohol/CNS Depressants
Enhanced sedative effects and increased risk of respiratory depression.
Antidepressants/Antipsychotics
Additive CNS depressant effects.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase bromazepam plasma levels and enhance its effects.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, slurred speech, and coma. Management involves supportive care, gastric lavage, and administration of flumazenil, a benzodiazepine antagonist, if clinically indicated.
Pregnancy & Lactation
Bromazepam is classified as Pregnancy Category D. It is not recommended during pregnancy due to potential risks of congenital malformations, neonatal withdrawal symptoms, and flaccidity. Avoid during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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