LG-M
Generic Name
Levocetirizine Dihydrochloride + Montelukast Sodium
Manufacturer
Example Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lg m 25 mg tablet | ৳ 8.00 | ৳ 48.00 |
Description
Overview of the medicine
LG-M is a combination medication containing Levocetirizine, an antihistamine, and Montelukast, a leukotriene receptor antagonist. It is primarily used to relieve symptoms of allergic rhinitis (seasonal and perennial) and for the prophylactic treatment of chronic asthma.
Uses & Indications
Dosage
Adults
One tablet (Levocetirizine 5 mg + Montelukast 10 mg) once daily, preferably in the evening.
Elderly
No dose adjustment is generally required in elderly patients, unless there is renal impairment.
Renal_impairment
Dose adjustment for Levocetirizine may be necessary based on creatinine clearance. Consult a physician.
How to Take
Take orally with or without food, preferably in the evening.
Mechanism of Action
Levocetirizine selectively antagonizes H1-receptors, thereby inhibiting the effects of histamine. Montelukast selectively antagonizes the cysteinyl leukotriene type 1 (CysLT1) receptor, blocking the action of leukotrienes, which are inflammatory mediators involved in asthma and allergic rhinitis.
Pharmacokinetics
Onset
Levocetirizine: ~1 hour. Montelukast: Clinical improvement may be seen within 1 day, full effect over several days.
Excretion
Levocetirizine is primarily excreted unchanged via urine. Montelukast is primarily excreted in the feces via bile.
Half life
Levocetirizine: ~7-10 hours. Montelukast: ~2.7-5.5 hours.
Absorption
Levocetirizine is rapidly and extensively absorbed after oral administration, reaching peak plasma concentrations in about 1 hour. Montelukast is rapidly absorbed, with peak plasma concentrations occurring 2-4 hours after oral administration.
Metabolism
Levocetirizine undergoes minimal metabolism. Montelukast is extensively metabolized in the liver by CYP3A4, 2C8, and 2C9.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, montelukast, or any component of the formulation.
- Severe renal impairment (creatinine clearance <10 ml/min).
- Severe hepatic impairment.
Drug Interactions
Rifampin
May decrease the plasma concentration of montelukast.
Phenobarbital
May decrease the bioavailability of montelukast.
CNS depressants
Concomitant use with levocetirizine may increase CNS depression (e.g., alcohol, sedatives).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, agitation, headache, abdominal pain. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Levocetirizine and Montelukast are excreted in breast milk. Caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, montelukast, or any component of the formulation.
- Severe renal impairment (creatinine clearance <10 ml/min).
- Severe hepatic impairment.
Drug Interactions
Rifampin
May decrease the plasma concentration of montelukast.
Phenobarbital
May decrease the bioavailability of montelukast.
CNS depressants
Concomitant use with levocetirizine may increase CNS depression (e.g., alcohol, sedatives).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, agitation, headache, abdominal pain. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Levocetirizine and Montelukast are excreted in breast milk. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved
Patent Status
Generic versions available, original compounds off-patent
Clinical Trials
Numerous clinical trials have established the efficacy and safety of both levocetirizine and montelukast individually and in combination for allergic rhinitis and asthma.
Lab Monitoring
- Liver function tests (for long-term montelukast use)
- Renal function tests (for levocetirizine, especially in elderly or renal impaired patients)
Doctor Notes
- Advise patients regarding the potential for neuropsychiatric events with montelukast and emphasize reporting any mood or behavior changes.
- Consider renal function when prescribing to elderly patients due to the levocetirizine component.
- Educate patients on proper inhaler technique if used concurrently with asthma inhalers.
Patient Guidelines
- Take the medication regularly as prescribed, even if symptoms improve.
- Do not stop taking the medicine suddenly, especially if used for asthma, without consulting your doctor.
- Be aware of potential neuropsychiatric side effects and report any changes in mood or behavior to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness or dizziness. Patients should be cautious when driving or operating machinery until they know how it affects them.
Lifestyle Advice
- Avoid known allergens to reduce the frequency and severity of allergic reactions.
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, to support overall respiratory health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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