Limpet
Generic Name
Zabaplon
Manufacturer
MediCorp Pharmaceuticals
Country
USA, Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| limpet 1 mg tablet | ৳ 4.00 | ৳ 56.00 |
Description
Overview of the medicine
Limpet 1 mg Tablet is an anxiolytic medication containing Zabaplon, indicated for the short-term treatment of generalized anxiety disorder and insomnia. It works by enhancing the effects of a natural chemical in the body (GABA) that calms brain activity.
Uses & Indications
Dosage
Adults
For GAD: 1 mg once daily, preferably at bedtime. May be adjusted to 0.5-2 mg/day based on response and tolerability. For insomnia: 1 mg at bedtime.
Elderly
Initial dose of 0.5 mg once daily, adjusted cautiously based on response. Elderly patients may be more sensitive to the effects.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment. Start with a lower dose and monitor for adverse effects.
How to Take
Take Limpet 1 mg Tablet orally with a glass of water, with or without food. Do not crush, chew, or break the tablet.
Mechanism of Action
Zabaplon acts as a positive allosteric modulator of the GABA-A receptor. It binds to a specific site on the receptor, distinct from the GABA binding site, enhancing the inhibitory effects of GABA. This leads to increased chloride ion influx into neurons, resulting in hyperpolarization and reduced neuronal excitability.
Pharmacokinetics
Onset
Anxiolytic effects typically observed within 30-60 minutes.
Excretion
Excreted predominantly via the kidneys as metabolites.
Half life
Approximately 10-20 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes, mainly CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Zabaplon or any components of the tablet
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Acute narrow-angle glaucoma
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of severe sedation, respiratory depression, coma, and death.
Alcohol and CNS Depressants
Increased risk of sedation, respiratory depression, and hypotension.
CYP3A4 Inducers (e.g., rifampicin, carbamazepine)
May decrease plasma concentrations of Zabaplon, potentially reducing efficacy.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase plasma concentrations of Zabaplon, leading to enhanced effects.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, diminished reflexes, and coma. Management involves supportive care, maintaining a patent airway, and monitoring vital signs. Flumazenil may be considered in severe cases, but caution is advised.
Pregnancy & Lactation
Pregnancy Category D. Zabaplon should be avoided during pregnancy, especially during the first trimester and near term, due to potential risk of congenital malformations and neonatal withdrawal symptoms. It is excreted in breast milk and should not be used during lactation.
Side Effects
Contraindications
- Hypersensitivity to Zabaplon or any components of the tablet
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Acute narrow-angle glaucoma
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of severe sedation, respiratory depression, coma, and death.
Alcohol and CNS Depressants
Increased risk of sedation, respiratory depression, and hypotension.
CYP3A4 Inducers (e.g., rifampicin, carbamazepine)
May decrease plasma concentrations of Zabaplon, potentially reducing efficacy.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase plasma concentrations of Zabaplon, leading to enhanced effects.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, diminished reflexes, and coma. Management involves supportive care, maintaining a patent airway, and monitoring vital signs. Flumazenil may be considered in severe cases, but caution is advised.
Pregnancy & Lactation
Pregnancy Category D. Zabaplon should be avoided during pregnancy, especially during the first trimester and near term, due to potential risk of congenital malformations and neonatal withdrawal symptoms. It is excreted in breast milk and should not be used during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Patented, under exclusivity
Clinical Trials
Phase III clinical trials have demonstrated the efficacy and safety of Zabaplon for generalized anxiety disorder and insomnia.
Lab Monitoring
- Liver function tests (LFTs) periodically with long-term use
- Renal function tests (RFTs) if renal impairment is present
Doctor Notes
- Advise patients on the potential for dependence and withdrawal symptoms. Emphasize short-term use.
- Monitor for signs of respiratory depression, especially with concomitant use of opioids.
- Educate patients about the risks of driving or operating machinery.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to withdrawal symptoms.
- Avoid alcohol and other CNS depressants while on this medication.
- Inform your doctor about all other medications you are taking.
- This medicine may cause drowsiness; avoid driving or operating heavy machinery.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Limpet 1 mg Tablet may cause drowsiness, dizziness, and impaired coordination. Patients should be advised to avoid driving or operating hazardous machinery until they know how the medication affects them.
Lifestyle Advice
- Engage in relaxation techniques and stress management.
- Maintain a regular sleep schedule and practice good sleep hygiene.
- Consider psychotherapy or counseling alongside medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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