Locin
Generic Name
Ofloxacin 0.5% Eye Drop
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| locin 05 eye drop | ৳ 90.00 | N/A |
Description
Overview of the medicine
Locin-05 Eye Drop contains Ofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections of the eye.
Uses & Indications
Dosage
Adults
For conjunctivitis: 1-2 drops into the affected eye(s) every 2-4 hours for the first two days, then 1-2 drops four times daily. For keratitis: 1-2 drops into the affected eye(s) every 30 minutes for the first two days, then 1-2 drops hourly for 4-6 days, then 1-2 drops four times daily.
Elderly
No specific dosage adjustment required for elderly patients.
Renal_impairment
No specific dosage adjustment required as systemic absorption is minimal.
How to Take
Wash hands before use. Tilt head back, pull down lower eyelid, and apply drops into the conjunctival sac. Close eye gently for a few minutes. Avoid touching the dropper tip to any surface.
Mechanism of Action
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid; typically within minutes of administration.
Excretion
Primarily renal excretion for systemically absorbed drug.
Half life
Not well-defined for topical ophthalmic use due to minimal systemic absorption, but ranges from 4-7 hours systemically.
Absorption
Minimal systemic absorption after ocular administration. Achieves high concentrations in tear film and ocular tissues.
Metabolism
Limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin or any other fluoroquinolone
- Hypersensitivity to any excipient of the eye drop
Drug Interactions
No significant systemic drug interactions expected due to minimal ocular absorption.
Topical corticosteroids might mask signs of infection and should be used with caution.
Storage
Store below 25°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Ocular overdose is unlikely to cause systemic toxicity due to limited absorption. Flush eye with lukewarm water if excessive amount is applied. Contact a healthcare professional if irritation persists.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Caution is advised during lactation as Ofloxacin is excreted in breast milk after systemic administration, though minimal with topical eye drops.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin or any other fluoroquinolone
- Hypersensitivity to any excipient of the eye drop
Drug Interactions
No significant systemic drug interactions expected due to minimal ocular absorption.
Topical corticosteroids might mask signs of infection and should be used with caution.
Storage
Store below 25°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Ocular overdose is unlikely to cause systemic toxicity due to limited absorption. Flush eye with lukewarm water if excessive amount is applied. Contact a healthcare professional if irritation persists.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Caution is advised during lactation as Ofloxacin is excreted in breast milk after systemic administration, though minimal with topical eye drops.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months unopened. Use within 28 days of opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Ofloxacin in treating bacterial ocular infections.
Lab Monitoring
- Not typically required for ophthalmic use.
Doctor Notes
- Confirm bacterial etiology before prescribing.
- Advise patients on proper administration technique to prevent contamination.
- Monitor for signs of superinfection.
Patient Guidelines
- Do not wear contact lenses during treatment of ocular infection.
- Avoid contaminating the dropper tip.
- Complete the full course of treatment even if symptoms improve.
Missed Dose Advice
Apply the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause temporary blurred vision or mild ocular discomfort. Patients should be advised to wait until vision clears before driving or operating machinery.
Lifestyle Advice
- Practice good ocular hygiene.
- Avoid rubbing eyes excessively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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