Locin
Generic Name
Levofloxacin 500 mg tablet
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| locin 500 mg tablet | ৳ 14.00 | ৳ 70.00 |
Description
Overview of the medicine
Locin 500 mg tablet contains Levofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Usually 500 mg once daily for 7-14 days depending on the infection type and severity.
Elderly
Dosage adjustment may be necessary in elderly patients with impaired renal function.
Renal_impairment
Dosage adjustment required based on creatinine clearance (e.g., lower dose or extended interval for CrCl < 50 mL/min).
How to Take
May be taken with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine, mainly via glomerular filtration and tubular secretion.
Half life
Approximately 6-8 hours.
Absorption
Rapidly and almost completely absorbed after oral administration. Bioavailability approx. 99%.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy
- Children and growing adolescents (due to risk of cartilage damage)
- Pregnancy and lactation (unless benefits outweigh risks)
Drug Interactions
NSAIDs
May increase risk of CNS stimulation and convulsions.
Warfarin
May enhance anticoagulant effect, increasing bleeding risk. Monitor INR.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antiarrhythmics (e.g., amiodarone, quinidine)
Increased risk of QT prolongation.
Antacids (containing magnesium/aluminum), sucralfate, iron supplements, zinc supplements
Reduce absorption of levofloxacin; take levofloxacin at least 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS effects (confusion, tremors, seizures), QT prolongation. Treatment involves symptomatic and supportive measures. Gastric lavage and hydration may be helpful. Hemodialysis is not effective.
Pregnancy & Lactation
Category C for pregnancy. Avoid during pregnancy and breastfeeding unless the potential benefit outweighs the risk. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy
- Children and growing adolescents (due to risk of cartilage damage)
- Pregnancy and lactation (unless benefits outweigh risks)
Drug Interactions
NSAIDs
May increase risk of CNS stimulation and convulsions.
Warfarin
May enhance anticoagulant effect, increasing bleeding risk. Monitor INR.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antiarrhythmics (e.g., amiodarone, quinidine)
Increased risk of QT prolongation.
Antacids (containing magnesium/aluminum), sucralfate, iron supplements, zinc supplements
Reduce absorption of levofloxacin; take levofloxacin at least 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS effects (confusion, tremors, seizures), QT prolongation. Treatment involves symptomatic and supportive measures. Gastric lavage and hydration may be helpful. Hemodialysis is not effective.
Pregnancy & Lactation
Category C for pregnancy. Avoid during pregnancy and breastfeeding unless the potential benefit outweighs the risk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of levofloxacin in treating various bacterial infections, including respiratory and urinary tract infections.
Lab Monitoring
- Renal function tests (for patients with renal impairment)
- Liver function tests (if signs of hepatotoxicity develop)
- ECG (in patients at risk for QT prolongation)
Doctor Notes
- Assess renal function before initiating therapy, especially in elderly patients.
- Counsel patients on the risk of tendon disorders and neurological adverse effects.
- Avoid co-administration with multivalent cations.
- Monitor for signs of hypersensitivity reactions.
Patient Guidelines
- Complete the full course of treatment, even if you feel better.
- Avoid excessive sun exposure; use sunscreen.
- Drink plenty of fluids.
- Report any new or worsening symptoms, especially pain in tendons.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, lightheadedness, or visual disturbances. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hygiene to prevent infections.
- Avoid driving or operating machinery if you experience dizziness or visual disturbances.
- Inform your doctor about all medications and supplements you are taking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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