Lorastine
Generic Name
Loratadine
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lorastine 10 mg tablet | ৳ 3.02 | ৳ 30.20 |
Description
Overview of the medicine
Loratadine is a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy or watery eyes, and itching of the nose or throat.
Uses & Indications
Dosage
Adults
10 mg once daily
Elderly
No dosage adjustment generally required, but caution in severe hepatic impairment.
Renal_impairment
For adults and children 6 years of age and over with liver or kidney failure, the initial dose should be 10 mg every other day.
How to Take
Administer orally, with or without food.
Mechanism of Action
Loratadine is a tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby alleviating allergy symptoms without significant sedation due to its poor penetration of the blood-brain barrier.
Pharmacokinetics
Onset
1-3 hours
Excretion
Approximately 40% excreted in urine and 42% in feces over 10 days, primarily as conjugated metabolites.
Half life
Loratadine: 8.4 hours; active metabolite (desloratadine): 28 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in 1-2 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4 and CYP2D6) to descarboethoxyloratadine (desloratadine), an active metabolite.
Side Effects
Contraindications
- Hypersensitivity to loratadine or any component of the formulation
- Children under 2 years of age (for tablets)
Drug Interactions
Cimetidine
Increased plasma concentrations of loratadine and desloratadine.
Erythromycin
Increased plasma concentrations of loratadine and desloratadine.
Ketoconazole
Increased plasma concentrations of loratadine and desloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, tachycardia, and headache. Gastric lavage and symptomatic/supportive treatment recommended.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted into breast milk, not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to loratadine or any component of the formulation
- Children under 2 years of age (for tablets)
Drug Interactions
Cimetidine
Increased plasma concentrations of loratadine and desloratadine.
Erythromycin
Increased plasma concentrations of loratadine and desloratadine.
Ketoconazole
Increased plasma concentrations of loratadine and desloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, tachycardia, and headache. Gastric lavage and symptomatic/supportive treatment recommended.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted into breast milk, not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, drugstores
Approval Status
Approved (Internationally and Locally)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- Liver function tests (in patients with hepatic impairment).
Doctor Notes
- Advise patients on proper administration and potential for mild sedation.
- Counsel on avoiding concomitant use of alcohol.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- If symptoms persist for more than 7 days, consult a doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause somnolence in some individuals, caution is advised when driving or operating machinery until individual response is known.
Lifestyle Advice
- Avoid known allergens.
- Keep your home clean to reduce dust mites.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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