Lorfast
Generic Name
Loratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lorfast 10 mg tablet | ৳ 3.01 | ৳ 30.15 |
Description
Overview of the medicine
Lorfast 10 mg Tablet contains Loratadine, a second-generation antihistamine. It is used to relieve symptoms associated with allergic rhinitis (like sneezing, runny or itchy nose, itchy watery eyes) and chronic idiopathic urticaria (hives). It is known for its non-sedating properties.
Uses & Indications
Dosage
Adults
10 mg once daily.
Elderly
No specific dose adjustment is generally required for elderly patients.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min) or hepatic impairment, a starting dose of 10 mg every other day is recommended.
How to Take
Take Lorfast 10 mg Tablet orally, with or without food, as directed by your doctor or pharmacist. Swallow the tablet whole with water.
Mechanism of Action
Loratadine is a selective peripheral H1-receptor antagonist. It works by blocking the action of histamine, a natural substance in the body that causes allergic symptoms. By blocking H1 receptors, it prevents histamine from binding and exerting its effects, thereby reducing allergic reactions.
Pharmacokinetics
Onset
Onset of action typically occurs within 1 to 3 hours.
Excretion
Approximately 80% of the dose is excreted equally in the urine and feces as metabolic products within 10 days.
Half life
Loratadine: 8 to 15 hours; Descarboethoxyloratadine (active metabolite): 17 to 24 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4, to its active metabolite, descarboethoxyloratadine.
Side Effects
Contraindications
- Hypersensitivity to Loratadine, desloratadine, or any component of the formulation.
- Severe hepatic impairment (caution required, dose adjustment may be necessary).
Drug Interactions
Cimetidine
May increase plasma concentrations of loratadine and descarboethoxyloratadine.
Erythromycin
May increase plasma concentrations of loratadine and descarboethoxyloratadine.
Ketoconazole
May increase plasma concentrations of loratadine and descarboethoxyloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In adults, somnolence, tachycardia, and headache have been reported. In the event of an overdose, symptomatic and supportive treatment should be initiated immediately. Gastric lavage may be considered if appropriate. Loratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Loratadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman. Consult your doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to Loratadine, desloratadine, or any component of the formulation.
- Severe hepatic impairment (caution required, dose adjustment may be necessary).
Drug Interactions
Cimetidine
May increase plasma concentrations of loratadine and descarboethoxyloratadine.
Erythromycin
May increase plasma concentrations of loratadine and descarboethoxyloratadine.
Ketoconazole
May increase plasma concentrations of loratadine and descarboethoxyloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In adults, somnolence, tachycardia, and headache have been reported. In the event of an overdose, symptomatic and supportive treatment should be initiated immediately. Gastric lavage may be considered if appropriate. Loratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Loratadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman. Consult your doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drug stores
Approval Status
FDA/DGDA Approved
Patent Status
Generic, patent expired
WHO Essential Medicine
YesClinical Trials
Loratadine has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No specific laboratory monitoring is routinely required for loratadine therapy.
Doctor Notes
- Advise patients that loratadine is generally non-sedating, but caution should be exercised until individual response is known.
- Consider dose adjustment in patients with severe hepatic or renal impairment.
- Loratadine is a good option for patients requiring daily allergy relief without significant drowsiness.
Patient Guidelines
- Do not exceed the recommended dose.
- If symptoms persist for more than 7 days or worsen, consult your doctor.
- Inform your doctor or pharmacist about all other medications you are taking, including herbal supplements and over-the-counter drugs.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Although loratadine is generally non-sedating, individual responses may vary. Patients should be advised to determine their response to the drug before engaging in activities requiring mental alertness, such as driving or operating machinery.
Lifestyle Advice
- Identify and avoid triggers for your allergies.
- Maintain good indoor air quality and use air filters if necessary.
- Get adequate rest and manage stress, as these can impact allergic reactions.
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