Lorfast
Generic Name
Loratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lorfast 5 mg suspension | ৳ 26.11 | N/A |
Description
Overview of the medicine
Loratadine is a non-drowsy antihistamine used for relief of allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.
Uses & Indications
Dosage
Adults
10 mg (10 ml of 5 mg/5 ml suspension) once daily.
Elderly
No dosage adjustment generally needed, but caution with severe hepatic impairment.
Renal_impairment
For severe renal impairment (creatinine clearance < 30 ml/min), initial dose 5 mg (5 ml of 5 mg/5 ml suspension) every other day.
Children_2_5_years
5 mg (5 ml of 5 mg/5 ml suspension) once daily.
Children_6_years_and_older
10 mg (10 ml of 5 mg/5 ml suspension) once daily.
How to Take
Administer orally, with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Loratadine selectively blocks peripheral H1-receptors, thereby inhibiting the effects of histamine which is responsible for allergic symptoms.
Pharmacokinetics
Onset
Onset of action within 1-3 hours.
Excretion
Approximately 40% in urine and 42% in feces over 10 days, mainly as conjugated metabolites.
Half life
Parent drug: approximately 8.4 hours; active metabolite (desloratadine): approximately 28 hours.
Absorption
Rapidly absorbed after oral administration. Food may slightly delay absorption.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2D6, to its major active metabolite, desloratadine.
Side Effects
Contraindications
- Hypersensitivity to loratadine, desloratadine, or any component of the formulation.
Drug Interactions
Cimetidine
May increase plasma concentrations of loratadine and desloratadine, but generally without clinically significant changes in ECG.
Erythromycin
May increase plasma concentrations of loratadine and desloratadine, but generally without clinically significant changes in ECG.
Ketoconazole
May increase plasma concentrations of loratadine and desloratadine, but generally without clinically significant changes in ECG.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, tachycardia, and headache. Management is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Loratadine is excreted in breast milk; therefore, use is not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to loratadine, desloratadine, or any component of the formulation.
Drug Interactions
Cimetidine
May increase plasma concentrations of loratadine and desloratadine, but generally without clinically significant changes in ECG.
Erythromycin
May increase plasma concentrations of loratadine and desloratadine, but generally without clinically significant changes in ECG.
Ketoconazole
May increase plasma concentrations of loratadine and desloratadine, but generally without clinically significant changes in ECG.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, tachycardia, and headache. Management is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Loratadine is excreted in breast milk; therefore, use is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for unopened container. Discard 6 months after opening or as per manufacturer's instructions.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Loratadine has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of allergic rhinitis and chronic idiopathic urticaria in both adults and pediatric populations.
Lab Monitoring
- Generally, no routine laboratory monitoring is required for patients taking loratadine.
Doctor Notes
- Counsel patients on proper administration using the provided measuring device, especially for pediatric dosing.
- Advise patients that while generally non-sedating, individual responses can vary; caution should be exercised with activities requiring mental alertness initially.
- Emphasize the importance of adherence to recommended dosage and duration of treatment.
Patient Guidelines
- Do not exceed the recommended dose.
- If symptoms persist or worsen after 3 days of treatment, consult your doctor.
- Shake the bottle well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Loratadine is generally non-sedating. However, individuals should assess their response to the medication before driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good hygiene and a healthy lifestyle.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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