Losapot-Plus
Generic Name
Losartan Potassium 50 mg + Hydrochlorothiazide 12.5 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| losapot plus 50 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Losapot-Plus 50 mg Tablet is a combination medicine containing Losartan Potassium and Hydrochlorothiazide, used to treat high blood pressure (hypertension). Losartan is an angiotensin II receptor blocker (ARB) which relaxes blood vessels, and Hydrochlorothiazide is a thiazide diuretic which helps the body get rid of excess water and salt.
Uses & Indications
Dosage
Adults
Usually 1 tablet (Losartan Potassium 50 mg + Hydrochlorothiazide 12.5 mg) once daily. The dose may be increased if needed after 3-4 weeks.
Elderly
No initial dosage adjustment is typically required, but monitoring of renal function and electrolytes is recommended.
Renal_impairment
Not recommended in patients with severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take orally, with or without food, usually once daily in the morning.
Mechanism of Action
Losartan, an ARB, selectively blocks the binding of angiotensin II to the AT1 receptor, inhibiting vasoconstriction and aldosterone secretion, leading to reduced blood pressure. Hydrochlorothiazide, a thiazide diuretic, increases the excretion of sodium, chloride, and water by inhibiting the sodium-chloride symporter in the distal convoluted tubule, thereby reducing plasma volume and blood pressure.
Pharmacokinetics
Onset
Losartan: 1-2 hours; Hydrochlorothiazide: 2 hours.
Excretion
Losartan and its active metabolite are excreted via urine (35%) and feces (60%). Hydrochlorothiazide is primarily excreted unchanged in urine.
Half life
Losartan: approximately 2 hours; active metabolite: 6-9 hours. Hydrochlorothiazide: 5.6-14.8 hours.
Absorption
Losartan is well absorbed orally, approximately 33% bioavailability. Hydrochlorothiazide is absorbed (60-80%) from the GI tract.
Metabolism
Losartan undergoes significant first-pass metabolism to an active carboxylic acid metabolite. Hydrochlorothiazide is not metabolized.
Side Effects
Contraindications
- Hypersensitivity to Losartan, Hydrochlorothiazide, or sulfonamide-derived drugs
- Anuria (inability to produce urine)
- Severe renal or hepatic impairment
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in diabetic patients
Drug Interactions
NSAIDs
May reduce the hypotensive effect and increase the risk of renal impairment.
Lithium
May increase serum lithium levels and toxicity.
Corticosteroids
Increased electrolyte depletion, particularly hypokalemia.
Other antihypertensives
Additive hypotensive effect.
Alcohol/Barbiturates/Narcotics
May potentiate orthostatic hypotension.
Potassium-sparing diuretics/Potassium supplements
May increase serum potassium levels (risk of hyperkalemia).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension, tachycardia, bradycardia, dehydration, and electrolyte disturbances (e.g., hypokalemia, hypochloremia). Treatment is supportive and symptomatic, focusing on restoring fluid and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category D (second and third trimesters): Contraindicated due to fetal toxicity. Not recommended during lactation as both components are excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Losartan, Hydrochlorothiazide, or sulfonamide-derived drugs
- Anuria (inability to produce urine)
- Severe renal or hepatic impairment
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in diabetic patients
Drug Interactions
NSAIDs
May reduce the hypotensive effect and increase the risk of renal impairment.
Lithium
May increase serum lithium levels and toxicity.
Corticosteroids
Increased electrolyte depletion, particularly hypokalemia.
Other antihypertensives
Additive hypotensive effect.
Alcohol/Barbiturates/Narcotics
May potentiate orthostatic hypotension.
Potassium-sparing diuretics/Potassium supplements
May increase serum potassium levels (risk of hyperkalemia).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension, tachycardia, bradycardia, dehydration, and electrolyte disturbances (e.g., hypokalemia, hypochloremia). Treatment is supportive and symptomatic, focusing on restoring fluid and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category D (second and third trimesters): Contraindicated due to fetal toxicity. Not recommended during lactation as both components are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on storage conditions.
Availability
Pharmacies, hospitals
Approval Status
Approved (for generic combination)
Patent Status
Patent expired for generic combination
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Losartan/Hydrochlorothiazide combination in managing hypertension.
Lab Monitoring
- Serum electrolytes (potassium, sodium)
- Renal function (creatinine, BUN)
- Blood pressure monitoring
Doctor Notes
- Monitor blood pressure and serum electrolytes regularly.
- Advise patients on lifestyle modifications to support blood pressure control.
- Educate patients about the risk of orthostatic hypotension.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment or when changing dosage. Use caution while driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Quit smoking.
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