Losatan
Generic Name
Losartan Potassium
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| losatan 25 mg tablet | ৳ 4.50 | ৳ 45.00 |
Description
Overview of the medicine
Losartan 25 mg tablet is an Angiotensin II Receptor Blocker (ARB) used to treat high blood pressure (hypertension) and to protect the kidneys from damage due to diabetes.
Uses & Indications
Dosage
Adults
Initial dose is usually 50 mg once daily. For Losartan 25 mg, it might be used as a starting dose or for dose titration, usually 25 mg once daily.
Elderly
No initial dose adjustment required for most elderly patients, but consider lower starting dose (e.g., 25 mg once daily) for those over 75 years.
Renal_impairment
No initial dose adjustment required in patients with mild to moderate renal impairment. For severe impairment, consider lower starting dose (e.g., 25 mg once daily).
How to Take
Losartan tablets can be taken with or without food, usually once daily. It is recommended to take the tablet at the same time each day.
Mechanism of Action
Losartan selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to decreased blood pressure.
Pharmacokinetics
Onset
Within 6 hours (full effect within 3-6 weeks)
Excretion
Approximately 35% in urine and 60% in feces (as unchanged drug and metabolites).
Half life
Losartan: 2 hours; active metabolite (E-3174): 6-9 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; undergoes extensive first-pass metabolism. Bioavailability is approximately 33%.
Metabolism
Hepatic (primarily by CYP2C9 and CYP3A4) to an active carboxylic acid metabolite (E-3174) and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component of the formulation
- Pregnancy (especially 2nd and 3rd trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported.
Aliskiren
Concomitant use with aliskiren is contraindicated in patients with diabetes or renal impairment.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of Losartan and increase the risk of renal impairment.
Potassium-sparing diuretics (e.g., spironolactone, amiloride) or potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure), tachycardia (rapid heartbeat), and possibly bradycardia (slow heartbeat). Treatment is symptomatic and supportive, focusing on maintaining blood pressure and hydration.
Pregnancy & Lactation
Contraindicated in the 2nd and 3rd trimesters of pregnancy due to fetal toxicity. Use during lactation is not recommended as it is unknown if Losartan is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component of the formulation
- Pregnancy (especially 2nd and 3rd trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported.
Aliskiren
Concomitant use with aliskiren is contraindicated in patients with diabetes or renal impairment.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of Losartan and increase the risk of renal impairment.
Potassium-sparing diuretics (e.g., spironolactone, amiloride) or potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure), tachycardia (rapid heartbeat), and possibly bradycardia (slow heartbeat). Treatment is symptomatic and supportive, focusing on maintaining blood pressure and hydration.
Pregnancy & Lactation
Contraindicated in the 2nd and 3rd trimesters of pregnancy due to fetal toxicity. Use during lactation is not recommended as it is unknown if Losartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, check specific packaging for details.
Availability
Pharmacies, hospitals, clinics
Approval Status
FDA Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Losartan has been extensively studied in clinical trials for its efficacy in treating hypertension, reducing cardiovascular events in high-risk patients, and managing diabetic nephropathy.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
- Renal function (BUN and creatinine)
- Liver function tests
Doctor Notes
- Advise patients to monitor blood pressure regularly.
- Check renal function and serum potassium levels periodically.
- Counsel patients on the importance of adherence to therapy and lifestyle modifications.
- Avoid in pregnancy due to fetal risk.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Losartan without consulting your doctor, even if you feel well.
- Monitor your blood pressure regularly at home and keep a record.
- Avoid potassium supplements or salt substitutes containing potassium unless advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Losartan may cause dizziness or lightheadedness, especially when starting the treatment or increasing the dose. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Maintain a healthy weight.
- Limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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