Losatan
Generic Name
Losartan Potassium
Manufacturer
Multiple Manufacturers
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| losatan 50 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Losartan 50 mg tablet is an Angiotensin II Receptor Blocker (ARB) used to treat high blood pressure (hypertension), reduce the risk of stroke in patients with high blood pressure and an enlarged heart, and manage kidney disease in type 2 diabetic patients.
Uses & Indications
Dosage
Adults
Initial dose: 50 mg once daily. Maintenance dose: 25-100 mg once daily, adjusted based on blood pressure response.
Elderly
Generally no initial dosage adjustment needed, but monitor closely, especially in those with intravascular volume depletion.
Renal_impairment
No initial dosage adjustment needed for mild-to-moderate renal impairment. For severe renal impairment or dialysis patients, a lower initial dose of 25 mg once daily may be considered.
How to Take
Take orally, with or without food, usually once daily. Swallow the tablet whole with a glass of water.
Mechanism of Action
Losartan is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased sodium and water retention, and ultimately a reduction in blood pressure.
Pharmacokinetics
Onset
1-2 hours for antihypertensive effect. Maximum effect in 3-6 weeks.
Excretion
Approximately 35% of the dose is excreted in the urine and 58% in the feces via bile.
Half life
Losartan: 2 hours; active metabolite (E-3174): 6-9 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is about 33%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9 and CYP3A4, to an active carboxylic acid metabolite (E-3174) and several inactive metabolites.
Side Effects
Contraindications
- Pregnancy (especially 2nd and 3rd trimesters)
- Hypersensitivity to losartan or any component of the formulation
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73m²)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Contraindicated in diabetic patients or those with renal impairment (GFR < 60) due to increased risk of renal impairment, hyperkalemia, and hypotension.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce antihypertensive effect and increase risk of renal impairment.
Diuretics (potassium-sparing) / Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and tachycardia (rapid heartbeat); bradycardia (slow heartbeat) may occur from parasympathetic stimulation. Treatment is symptomatic and supportive, focusing on maintaining cardiovascular stability.
Pregnancy & Lactation
Pregnancy: Contraindicated during the second and third trimesters due to risk of fetal injury and death. Discontinue immediately if pregnancy is detected. Lactation: Not recommended during breastfeeding due to potential risk to the nursing infant.
Side Effects
Contraindications
- Pregnancy (especially 2nd and 3rd trimesters)
- Hypersensitivity to losartan or any component of the formulation
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73m²)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Contraindicated in diabetic patients or those with renal impairment (GFR < 60) due to increased risk of renal impairment, hyperkalemia, and hypotension.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce antihypertensive effect and increase risk of renal impairment.
Diuretics (potassium-sparing) / Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and tachycardia (rapid heartbeat); bradycardia (slow heartbeat) may occur from parasympathetic stimulation. Treatment is symptomatic and supportive, focusing on maintaining cardiovascular stability.
Pregnancy & Lactation
Pregnancy: Contraindicated during the second and third trimesters due to risk of fetal injury and death. Discontinue immediately if pregnancy is detected. Lactation: Not recommended during breastfeeding due to potential risk to the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent, generic available
WHO Essential Medicine
YesClinical Trials
Losartan has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in hypertension, stroke prevention, and diabetic nephropathy. Ongoing research explores its broader cardiovascular protective effects.
Lab Monitoring
- Blood pressure monitoring
- Serum potassium levels (especially in patients with renal impairment, on potassium-sparing diuretics, or with diabetes)
- Renal function (creatinine, BUN) monitoring periodically
Doctor Notes
- Monitor blood pressure regularly, especially during initiation and dose titration.
- Assess renal function and serum potassium levels periodically, particularly in patients with pre-existing renal impairment, heart failure, or those on concomitant potassium-sparing diuretics.
- Advise patients on the importance of adherence and not discontinuing therapy abruptly.
Patient Guidelines
- Take your medicine regularly as directed by your doctor, even if you feel well.
- Do not stop taking Losartan without consulting your doctor, as it can cause a sudden increase in blood pressure.
- Inform your doctor immediately if you become pregnant or plan to become pregnant.
- Avoid potassium supplements or salt substitutes containing potassium without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Driving Precautions
Losartan may cause dizziness, especially when you first start taking it or when the dose is increased. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Limit alcohol consumption.
- Quit smoking to improve cardiovascular health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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