Losita
Generic Name
Losita-5-mg-tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| losita 5 mg tablet | ৳ 7.00 | ৳ 98.00 |
Description
Overview of the medicine
Losita 5 mg Tablet is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes.
Uses & Indications
Dosage
Adults
Typical initial dose for hypertension is 25-50 mg once daily. Max dose usually 100 mg daily. A 5 mg dose may be used in specific cases for very sensitive patients or as a starting point under strict medical supervision.
Elderly
No specific dose adjustment is usually required, but a lower starting dose (e.g., 25 mg) may be considered for frail or volume-depleted elderly patients. A 5 mg dose could be considered for very sensitive elderly patients.
Renal_impairment
No initial dose adjustment generally needed for mild-to-moderate renal impairment. For severe impairment, a lower starting dose (e.g., 25 mg) may be considered. Regular monitoring of renal function and potassium levels is recommended.
How to Take
Losita 5 mg Tablet should be taken orally once daily, with or without food. It is important to take it at the same time each day.
Mechanism of Action
Losita selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland, kidneys, and heart). This prevents the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect usually apparent within 1 week, maximal effect by 3-6 weeks.
Excretion
Approximately 35% excreted in urine and 60% in feces, primarily as metabolites.
Half life
Losita and its active metabolite have elimination half-lives of approximately 2 hours and 6-9 hours, respectively.
Absorption
Well absorbed from the gastrointestinal tract; undergoes significant first-pass metabolism. Bioavailability is approximately 33%.
Metabolism
Extensively metabolized by cytochrome P450 enzymes (CYP2C9 and CYP3A4) to an active carboxylic acid metabolite (E-3174) and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to losartan or any component of the formulation
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m2) due to increased risk of hypotension, hyperkalemia, and renal impairment.
Diuretics (potassium-sparing)
Increased risk of hyperkalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, gastric lavage may be considered. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category D (2nd and 3rd trimesters): Losita can cause fetal harm when administered to a pregnant woman. Discontinue as soon as pregnancy is detected. It is not known whether Losita is excreted in human breast milk; however, it is advised to avoid breastfeeding during treatment.
Side Effects
Contraindications
- Hypersensitivity to losartan or any component of the formulation
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m2) due to increased risk of hypotension, hyperkalemia, and renal impairment.
Diuretics (potassium-sparing)
Increased risk of hyperkalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Treatment is symptomatic and supportive. If ingestion is recent, gastric lavage may be considered. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category D (2nd and 3rd trimesters): Losita can cause fetal harm when administered to a pregnant woman. Discontinue as soon as pregnancy is detected. It is not known whether Losita is excreted in human breast milk; however, it is advised to avoid breastfeeding during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent (Generic available)
Clinical Trials
Losartan has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in hypertension, diabetic nephropathy, and reduction of cardiovascular morbidity and mortality.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment, on potassium-sparing diuretics, or on potassium supplements)
- Renal function (BUN and serum creatinine)
- Blood pressure (regular monitoring)
Doctor Notes
- Advise patients about the importance of consistent daily dosing.
- Monitor blood pressure regularly and assess for orthostatic hypotension, especially in elderly patients.
- Counsel patients on potential drug interactions, particularly with NSAIDs and potassium-sparing diuretics.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor, even if you feel better.
- Inform your doctor about all other medicines, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Losita may cause dizziness or lightheadedness, especially when starting treatment or increasing the dose. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Adopt a healthy diet low in sodium and rich in fruits and vegetables.
- Engage in regular physical activity as advised by your doctor.
- Limit alcohol consumption and avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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