Medicine Information

Lotenate Plus

Name: Lotenate Plus
Brand: Lotenate Plus
Rating: 4.5 (117 reviews)

Ophthalmic SuspensionLoteprednol Etabonate 0.5% w/v and Tobramycin 0.3% w/vOphthalmic Corticosteroids with Anti-infectivesATC: S01CA05

Generic Name

Loteprednol Etabonate 0.5% + Tobramycin 0.3% Ophthalmic Suspension

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lotenate plus 05 03 suspension	৳ 200.00	N/A

Description

Overview of the medicine

Lotenate Plus is an ophthalmic suspension combining a corticosteroid (Loteprednol Etabonate) and an aminoglycoside antibiotic (Tobramycin). It is used to treat steroid-responsive inflammatory ocular conditions where bacterial ocular infection or a risk of bacterial ocular infection exists.

Uses & Indications

Steroid-responsive inflammatory ocular conditions where bacterial ocular infection or a risk of bacterial ocular infection exists.

Conjunctivitis

Keratitis

Anterior Uveitis

Post-operative inflammation following ocular surgery

Dosage

Adults

Instill 1 drop into the affected eye(s) 3-4 times daily. In severe cases, dosage may be increased to 1 drop every hour for the first 24-48 hours, then tapered as inflammation subsides.

Elderly

No specific dosage adjustment is necessary for elderly patients.

Renal_impairment

No dosage adjustment is necessary for ophthalmic administration as systemic absorption is minimal.

How to Take

Shake the bottle well before each use. Tilt your head back, pull down your lower eyelid to form a pocket, and instill one drop into the pocket. Do not touch the dropper tip to any surface (eye, finger, etc.) to avoid contamination. Close your eye gently and apply pressure to the tear duct for a minute to prevent drainage. If using other eye drops, wait at least 5 minutes between applications.

Mechanism of Action

Loteprednol Etabonate is a corticosteroid that inhibits the inflammatory response by suppressing migration of fibroblasts and leukocytes, reversing capillary permeability, and lysosomal stabilization. Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by irreversibly binding to the 30S ribosomal subunit, leading to bacterial cell death.

Pharmacokinetics

Onset

Anti-inflammatory and antibacterial effects can be observed within hours of administration.

Excretion

Systemically absorbed components (if any) are primarily excreted unchanged in urine, but ocular route leads to minimal systemic exposure.

Half life

Systemic half-life not clinically relevant for ophthalmic use due to minimal absorption.

Absorption

Minimal systemic absorption after ocular administration. Loteprednol Etabonate is rapidly metabolized to inactive compounds. Tobramycin also has limited systemic absorption from the eye.

Metabolism

Loteprednol Etabonate undergoes extensive metabolism to inactive carboxylic acid metabolites. Tobramycin is not significantly metabolized.

Side Effects

Contraindications

Viral keratitis (e.g., Herpes Simplex Keratitis)
Fungal ocular infections
Mycobacterial ocular infections
Hypersensitivity to any component of the medication

Drug Interactions

Other Ophthalmic Medications

If more than one topical ophthalmic drug is being used, they should be administered at least 5 minutes apart.

Storage

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Ocular overdose is unlikely to cause acute problems. If accidentally ingested, drink fluids to dilute. If an ocular overdose occurs, the eye can be flushed with lukewarm water.

Pregnancy & Lactation

Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a physician.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 mL bottle10 mL bottle

Shelf Life

Typically 24 months (unopened). Discard 28 days after opening.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent (generic available)

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of Loteprednol Etabonate and Tobramycin combination in treating steroid-responsive inflammatory ocular conditions with concurrent or risk of bacterial infection.

Lab Monitoring

Intraocular pressure (IOP) monitoring is recommended if used for 10 days or longer.

Doctor Notes

Emphasize short-term use, typically not more than 10-14 days.
Monitor intraocular pressure (IOP) in patients receiving prolonged treatment.
Be aware of the potential for masking fungal or viral ocular infections.

Patient Guidelines

Shake well before use.
Do not touch the dropper tip to any surface.
Remove contact lenses before application and reinsert 15 minutes after.
Complete the full course of treatment as prescribed, even if symptoms improve.
Do not discontinue use abruptly without consulting your doctor.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

This medication may cause temporary blurred vision. Avoid driving or operating machinery until your vision is clear.

Lifestyle Advice

Avoid rubbing your eyes.
Maintain good eye hygiene to prevent further infection.
Do not share eye drops with others.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Tobra-D (Square Pharmaceuticals Ltd. - Tobramycin + Dexamethasone)Cortimyc (Acme Laboratories Ltd. - Tobramycin + Dexamethasone)Dexachlor (Beximco Pharmaceuticals Ltd. - Chloramphenicol + Dexamethasone)