Lotepro
Generic Name
Losartan Potassium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lotepro 05 suspension | ৳ 175.00 | N/A |
Description
Overview of the medicine
Lotepro (Losartan Potassium) is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension), reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, and treat kidney disease in patients with type 2 diabetes and hypertension.
Uses & Indications
Dosage
Adults
Initial 50 mg once daily, maintenance 25-100 mg once daily.
Elderly
Initial 25 mg once daily, then adjust.
Renal_impairment
No initial dosage adjustment needed for mild to moderate, consider lower dose for severe.
How to Take
Oral, with or without food.
Mechanism of Action
Blocks the binding of angiotensin II to the AT1 receptor, preventing vasoconstriction and aldosterone secretion, thus lowering blood pressure.
Pharmacokinetics
Onset
6 hours to peak effect.
Excretion
Fecal (major) and urinary (minor).
Half life
Losartan ~2 hours, active metabolite E-3174 ~6-9 hours.
Absorption
Well absorbed orally, ~33% bioavailability.
Metabolism
Hepatic, to an active carboxylic acid metabolite (E-3174) by CYP2C9 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component
- Pregnancy (especially 2nd and 3rd trimesters)
- Concomitant use with aliskiren in diabetic patients
Drug Interactions
NSAIDs
May reduce antihypertensive effect and increase risk of renal impairment.
Diuretics
Increased risk of hypotension.
ACE Inhibitors
Increased risk of hyperkalemia, renal dysfunction, and hypotension.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store at room temperature (below 30°C), away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension, tachycardia; bradycardia could occur. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated during pregnancy. Not recommended during breastfeeding due to potential harm to the infant.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component
- Pregnancy (especially 2nd and 3rd trimesters)
- Concomitant use with aliskiren in diabetic patients
Drug Interactions
NSAIDs
May reduce antihypertensive effect and increase risk of renal impairment.
Diuretics
Increased risk of hypotension.
ACE Inhibitors
Increased risk of hyperkalemia, renal dysfunction, and hypotension.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store at room temperature (below 30°C), away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension, tachycardia; bradycardia could occur. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated during pregnancy. Not recommended during breastfeeding due to potential harm to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Available in pharmacies worldwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated its efficacy and safety in various patient populations with hypertension and related conditions.
Lab Monitoring
- Serum creatinine
- Blood urea nitrogen (BUN)
- Serum potassium
Doctor Notes
- Monitor renal function and serum potassium periodically, especially in patients with pre-existing renal impairment or those on diuretics.
- Avoid in pregnancy.
- Consider lower initial doses in elderly or volume-depleted patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor.
- Regularly monitor your blood pressure at home.
- Avoid potassium supplements unless advised by a doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take two doses at once.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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