Lotepro G
Generic Name
Losartan Potassium + Hydrochlorothiazide
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lotepro g 05 03 suspension | ৳ 250.00 | N/A |
Description
Overview of the medicine
Lotepro G is a combination medication used to treat high blood pressure. It contains Losartan, an angiotensin II receptor blocker, and Hydrochlorothiazide, a thiazide diuretic.
Uses & Indications
Dosage
Adults
Typically, one tablet (50 mg Losartan/12.5 mg Hydrochlorothiazide) once daily. Dosage may be increased to 100 mg/25 mg daily if needed.
Elderly
No initial dosage adjustment is generally required, but close monitoring of renal function and electrolytes is recommended.
Renal_impairment
Not recommended for patients with severe renal impairment (creatinine clearance < 30 mL/min). Dose adjustment may be needed for moderate impairment.
How to Take
Lotepro G can be taken orally, with or without food. It is usually taken once daily.
Mechanism of Action
Losartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the AT1 receptor. Hydrochlorothiazide is a diuretic that acts by inhibiting sodium reabsorption in the distal convoluted tubules, increasing the excretion of sodium, chloride, and water.
Pharmacokinetics
Onset
Losartan: 1-2 hours. Hydrochlorothiazide: 2 hours.
Excretion
Losartan and its active metabolite are primarily excreted in urine and feces. Hydrochlorothiazide is excreted predominantly unchanged in urine.
Half life
Losartan: approximately 2 hours (active metabolite 6-9 hours). Hydrochlorothiazide: 6-15 hours.
Absorption
Losartan is well absorbed from the gastrointestinal tract, with a bioavailability of about 33%. Hydrochlorothiazide is absorbed moderately (60-80%).
Metabolism
Losartan undergoes significant first-pass metabolism to an active carboxylic acid metabolite. Hydrochlorothiazide is minimally metabolized.
Side Effects
Contraindications
- Hypersensitivity to any component of the product.
- Anuria or severe renal impairment.
- Pregnancy (especially 2nd and 3rd trimesters).
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
Lithium
Increases lithium serum concentrations and lithium toxicity.
Alcohol, barbiturates, or narcotics
May potentiate orthostatic hypotension.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the diuretic and antihypertensive effects; risk of worsening renal function.
Potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes
May lead to hyperkalemia (high potassium levels).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure), tachycardia (rapid heartbeat), and possibly bradycardia (slow heartbeat). Management is symptomatic and supportive, including IV fluids and vasopressors if severe hypotension occurs.
Pregnancy & Lactation
Category D in pregnancy (risk to fetus). Contraindicated in the 2nd and 3rd trimesters. Not recommended during breastfeeding as both drugs are excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to any component of the product.
- Anuria or severe renal impairment.
- Pregnancy (especially 2nd and 3rd trimesters).
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
Lithium
Increases lithium serum concentrations and lithium toxicity.
Alcohol, barbiturates, or narcotics
May potentiate orthostatic hypotension.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the diuretic and antihypertensive effects; risk of worsening renal function.
Potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes
May lead to hyperkalemia (high potassium levels).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure), tachycardia (rapid heartbeat), and possibly bradycardia (slow heartbeat). Management is symptomatic and supportive, including IV fluids and vasopressors if severe hypotension occurs.
Pregnancy & Lactation
Category D in pregnancy (risk to fetus). Contraindicated in the 2nd and 3rd trimesters. Not recommended during breastfeeding as both drugs are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired for generic components
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Losartan/Hydrochlorothiazide combination therapy in the management of hypertension and associated cardiovascular risks.
Lab Monitoring
- Serum electrolytes (especially potassium and sodium)
- Renal function tests (serum creatinine, BUN)
- Liver function tests
Doctor Notes
- Emphasize the importance of consistent medication adherence to patients.
- Advise patients to report any symptoms of angioedema or severe allergic reactions immediately.
- Regularly assess renal function and electrolyte levels, especially in patients with pre-existing renal impairment or those on concomitant medications affecting potassium levels.
Patient Guidelines
- Take the medicine regularly as prescribed, even if you feel well.
- Do not stop taking Lotepro G suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Lotepro G may cause dizziness or lightheadedness, especially at the start of treatment or when changing doses. Avoid driving or operating machinery if you experience these symptoms.
Lifestyle Advice
- Maintain a low-salt diet.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Quit smoking.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.