Lubicon
Generic Name
Lubiprostone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lubicon 24 mcg capsule | ৳ 40.00 | ৳ 240.00 |
Description
Overview of the medicine
Lubicon 24 mcg Capsule contains Lubiprostone, a chloride channel activator used to treat chronic idiopathic constipation (CIC), opioid-induced constipation (OIC) in adults with chronic non-cancer pain, and irritable bowel syndrome with constipation (IBS-C) in women 18 years of age and older.
Uses & Indications
Dosage
Adults
For CIC and OIC: 24 mcg orally twice daily with food and water. For IBS-C (if prescribed 24mcg, typically 8mcg is used): 8 mcg orally twice daily with food and water.
Elderly
No specific dosage adjustment recommended based on age alone. Caution should be exercised due to potential increased susceptibility to adverse effects.
Renal_impairment
No dosage adjustment recommended for mild-to-moderate renal impairment. For severe renal impairment, consider a reduced starting dose.
How to Take
Take orally, with food and water. Swallow the capsule whole; do not break or chew.
Mechanism of Action
Lubiprostone acts locally on the apical membrane of gastrointestinal epithelial cells by activating ClC-2 chloride channels. This increases intestinal fluid secretion and motility, leading to softened stool and increased spontaneous bowel movements.
Pharmacokinetics
Onset
First spontaneous bowel movement within 24-48 hours.
Excretion
Mainly excreted via feces as metabolites; minimal urinary excretion.
Half life
Very short; plasma half-life of active metabolite is approximately 0.9-1.4 hours.
Absorption
Minimally absorbed systemically. Peak plasma concentrations are very low and occur rapidly.
Metabolism
Rapidly metabolized in the stomach and jejunum by carbonyl reductase, with minimal hepatic metabolism.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Severe diarrhea.
Drug Interactions
Methadone
May decrease the efficacy of Lubiprostone, especially in OIC patients.
Other laxatives
Concurrent use not generally recommended without medical advice.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for Lubiprostone overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown if Lubiprostone is excreted in human milk; use with caution in breastfeeding women.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Severe diarrhea.
Drug Interactions
Methadone
May decrease the efficacy of Lubiprostone, especially in OIC patients.
Other laxatives
Concurrent use not generally recommended without medical advice.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for Lubiprostone overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown if Lubiprostone is excreted in human milk; use with caution in breastfeeding women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Available in pharmacies with prescription
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired in many regions, generics available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Lubiprostone in treating chronic idiopathic constipation and opioid-induced constipation.
Lab Monitoring
- Routine laboratory monitoring is generally not required due to minimal systemic absorption.
Doctor Notes
- Emphasize taking with food and water to reduce nausea.
- Monitor patients for severe diarrhea, especially during initial treatment.
- Counsel patients on the possibility of dyspnea and to seek immediate medical attention if it occurs.
Patient Guidelines
- Take the capsule whole with food and water.
- Do not crush, chew, or break the capsule.
- Report severe diarrhea or difficulty breathing to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Lubiprostone may cause dizziness or fatigue. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain adequate hydration.
- Follow a balanced diet rich in fiber (unless contraindicated for IBS-C).
- Engage in regular physical activity.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Lubicon Brand
Other medicines available under the same brand name
