Lubicon
Generic Name
Lubiprostone
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lubicon 8 mcg capsule | ৳ 15.00 | ৳ 90.00 |
Description
Overview of the medicine
Lubicon 8 mcg capsule contains Lubiprostone, a prostaglandin E1 derivative, used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It works by increasing fluid secretion into the intestines, softening stool, and promoting bowel movements.
Uses & Indications
Dosage
Adults
For CIC and OIC: 24 mcg orally twice daily with food and water. For IBS-C: 8 mcg orally twice daily with food and water.
Elderly
No specific dosage adjustment is required based on age alone, but caution is advised due to potential for comorbidities.
Renal_impairment
No dosage adjustment is required in patients with renal impairment.
How to Take
Lubicon capsules should be taken orally twice daily with food and water. Swallow the capsule whole; do not break or chew.
Mechanism of Action
Lubiprostone is a locally acting chloride channel activator that specifically activates ClC-2 chloride channels on the apical membrane of gastrointestinal epithelial cells. This activation leads to an increase in intestinal fluid secretion, which softens the stool and enhances motility, facilitating spontaneous bowel movements.
Pharmacokinetics
Onset
First spontaneous bowel movement within 24-48 hours, with continued improvement over time.
Excretion
Mainly excreted via feces and urine as metabolites.
Half life
Approximately 0.9 to 1.4 hours for active metabolites.
Absorption
Minimal systemic absorption; plasma concentrations are typically below the quantifiable limit (50 pg/mL).
Metabolism
Primarily metabolized by aldoketo reductases in the gastrointestinal tract and liver, not by the cytochrome P450 system.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Hypersensitivity to lubiprostone or any component of the capsule.
Drug Interactions
Methadone
May reduce the efficacy of lubiprostone, particularly in opioid-induced constipation.
Antidiarrheals
Concomitant use with antidiarrheal agents is not recommended as it may counteract the effects of lubiprostone.
Storage
Store at controlled room temperature (20°C to 25°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally an exaggeration of common side effects, primarily diarrhea and nausea. Treatment is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if lubiprostone is excreted in human milk; caution is advised when administered to a nursing woman.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Hypersensitivity to lubiprostone or any component of the capsule.
Drug Interactions
Methadone
May reduce the efficacy of lubiprostone, particularly in opioid-induced constipation.
Antidiarrheals
Concomitant use with antidiarrheal agents is not recommended as it may counteract the effects of lubiprostone.
Storage
Store at controlled room temperature (20°C to 25°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally an exaggeration of common side effects, primarily diarrhea and nausea. Treatment is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if lubiprostone is excreted in human milk; caution is advised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patent expired for original formulation; generic versions available.
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of lubiprostone in treating CIC, IBS-C, and OIC. Key trials include placebo-controlled studies showing increased spontaneous bowel movements and improved stool consistency.
Lab Monitoring
- No routine laboratory monitoring is typically required for lubiprostone.
Doctor Notes
- Counsel patients on the importance of taking with food to reduce nausea.
- Exclude mechanical obstruction before initiating treatment.
- Monitor for dehydration in patients experiencing significant diarrhea.
Patient Guidelines
- Take with food and water to minimize nausea.
- Swallow the capsule whole; do not chew, break, or crush.
- Inform your doctor if you experience severe diarrhea or worsening abdominal pain.
- Stay hydrated during treatment.
Missed Dose Advice
If a dose is missed, skip the missed dose and continue with the next scheduled dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Lubiprostone may cause dizziness or fatigue in some patients. If these symptoms occur, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a high-fiber diet
- Engage in regular physical activity
- Ensure adequate fluid intake.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Lubicon Brand
Other medicines available under the same brand name
