Lubilax
Generic Name
Lubiprostone
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lubilax 24 mcg capsule | ৳ 40.12 | ৳ 401.20 |
Description
Overview of the medicine
Lubiprostone is a chloride channel activator used to treat chronic idiopathic constipation, irritable bowel syndrome with constipation (IBS-C), and opioid-induced constipation in adults.
Uses & Indications
Dosage
Adults
For Chronic Idiopathic Constipation (CIC) and Opioid-Induced Constipation (OIC): 24 mcg orally twice daily with food and water. For Irritable Bowel Syndrome with Constipation (IBS-C): 8 mcg orally twice daily with food and water.
Elderly
No dosage adjustment generally required, but caution due to potential for increased sensitivity. Monitor for efficacy and adverse effects.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Use with caution in severe impairment. Monitor for adverse effects.
How to Take
Take orally with food and water to reduce the incidence of nausea. Do not crush, chew, or break the capsule.
Mechanism of Action
Lubiprostone activates ClC-2 chloride channels on the apical membrane of gastrointestinal epithelial cells, leading to an efflux of chloride and fluid into the intestinal lumen. This softens stool, increases motility, and facilitates spontaneous bowel movements.
Pharmacokinetics
Onset
Typically within 24-48 hours for chronic idiopathic constipation.
Excretion
Primarily via feces (approximately 60%) and urine (approximately 3%) as metabolites.
Half life
Approximately 0.9 to 1.4 hours for active metabolite.
Absorption
Minimally absorbed systemically after oral administration. Peak plasma concentrations are very low and often below the limit of quantification.
Metabolism
Extensively metabolized in the stomach and jejunum by carbonyl reductase, forming active metabolites. Systemic metabolism is minimal.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Severe diarrhea.
- Hypersensitivity to lubiprostone or any component of the capsule.
Drug Interactions
Methadone
May decrease the effectiveness of lubiprostone, consider alternative laxatives or higher lubiprostone dose.
Antidiarrheals (e.g., Loperamide)
May counteract the effect of lubiprostone.
Storage
Store at controlled room temperature (20°C to 25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to be exaggerated adverse effects, such as severe diarrhea, nausea, and vomiting. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is not known whether lubiprostone is excreted in human milk; exercise caution when administered to a nursing woman.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Severe diarrhea.
- Hypersensitivity to lubiprostone or any component of the capsule.
Drug Interactions
Methadone
May decrease the effectiveness of lubiprostone, consider alternative laxatives or higher lubiprostone dose.
Antidiarrheals (e.g., Loperamide)
May counteract the effect of lubiprostone.
Storage
Store at controlled room temperature (20°C to 25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to be exaggerated adverse effects, such as severe diarrhea, nausea, and vomiting. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is not known whether lubiprostone is excreted in human milk; exercise caution when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patent Expired (generics available)
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety of lubiprostone in treating chronic idiopathic constipation, IBS-C, and opioid-induced constipation.
Lab Monitoring
- Generally no specific lab monitoring required. Monitor for efficacy and side effects.
Doctor Notes
- Confirm diagnosis and rule out mechanical obstruction before initiation.
- Advise patients on proper administration with food and water to minimize nausea.
- Monitor for treatment response and adverse effects, especially diarrhea.
Patient Guidelines
- Take with food and water to minimize nausea.
- Do not crush, chew, or break the capsule.
- Report severe diarrhea or worsening symptoms to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or syncope in some patients; use caution when driving or operating machinery.
Lifestyle Advice
- Maintain adequate fluid intake.
- Incorporate fiber-rich foods into your diet (unless advised otherwise by doctor).
- Engage in regular physical activity.
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Global Brand Names
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