Lubilax
Generic Name
Lubiprostone
Manufacturer
Example Pharmaceutical Co.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lubilax 8 mcg capsule | ৳ 15.05 | ৳ 150.50 |
Description
Overview of the medicine
Lubiprostone is a chloride channel activator used to treat chronic idiopathic constipation, irritable bowel syndrome with constipation (IBS-C) in women, and opioid-induced constipation (OIC) in adults.
Uses & Indications
Dosage
Adults
CIC: 24 mcg orally twice daily. IBS-C (women): 8 mcg orally twice daily. OIC: 24 mcg orally twice daily.
Elderly
No specific dosage adjustment based on age alone, but monitor for side effects.
Renal_impairment
For severe renal impairment (CrCl <29 mL/min): reduce dose to 8 mcg twice daily. No adjustment for mild to moderate impairment.
How to Take
Take orally with food and water. Swallow the capsule whole; do not chew or crush it.
Mechanism of Action
It activates chloride channels (ClC-2) in the apical membrane of the gastrointestinal tract, increasing intestinal fluid secretion, which softens the stool and promotes spontaneous bowel movements.
Pharmacokinetics
Onset
First spontaneous bowel movement often occurs within 24-48 hours.
Excretion
Primarily eliminated via feces (60%) and urine (30%) as metabolites.
Half life
Very short, parent drug is rapidly metabolized.
Absorption
Minimal systemic absorption, primarily acts locally in the gut.
Metabolism
Rapidly metabolized in the stomach and jejunum via reduction/oxidation by carbonyl reductase.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Severe diarrhea.
Drug Interactions
Opioids
May reduce the efficacy of lubiprostone by counteracting its effects on gut motility and fluid secretion. Consider increased dosage or alternative treatments.
Storage
Store below 30°C (86°F). Protect from moisture and light. Keep out of reach of children.
Overdose
In case of overdose, provide symptomatic and supportive treatment. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefit justifies the potential risk to the fetus. It is unknown if lubiprostone is excreted in human milk; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Known or suspected mechanical gastrointestinal obstruction.
- Severe diarrhea.
Drug Interactions
Opioids
May reduce the efficacy of lubiprostone by counteracting its effects on gut motility and fluid secretion. Consider increased dosage or alternative treatments.
Storage
Store below 30°C (86°F). Protect from moisture and light. Keep out of reach of children.
Overdose
In case of overdose, provide symptomatic and supportive treatment. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefit justifies the potential risk to the fetus. It is unknown if lubiprostone is excreted in human milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies
Approval Status
FDA approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of lubiprostone for CIC, IBS-C, and OIC across various patient populations.
Lab Monitoring
- No routine laboratory monitoring is typically required.
Doctor Notes
- Prior to initiating treatment, ensure no mechanical obstruction is present to avoid potential complications.
- Advise patients to take lubiprostone with food and water to mitigate gastrointestinal side effects, especially nausea.
- Consider dose reduction in patients with severe hepatic or renal impairment.
Patient Guidelines
- Take your medicine with food and water to minimize nausea.
- Swallow capsules whole; do not chew, break, or crush them.
- Report any severe or persistent diarrhea, nausea, or shortness of breath to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Lubiprostone may cause dizziness, particularly at the start of treatment. Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that lubiprostone therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain adequate fluid intake throughout the day.
- Incorporate fiber-rich foods into your diet, if appropriate and advised by your doctor.
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