Lumona
Generic Name
Levocetirizine Dihydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lumona 10 mg tablet | ৳ 12.00 | ৳ 168.00 |
Description
Overview of the medicine
Lumona 10 mg Tablet contains Levocetirizine Dihydrochloride, a non-drowsy antihistamine used to relieve symptoms associated with allergic conditions such as allergic rhinitis and chronic idiopathic urticaria. It helps alleviate sneezing, runny nose, itchy watery eyes, and itching.
Uses & Indications
Dosage
Adults
The usual recommended dose for adults and children 12 years and older is 10 mg (one tablet) once daily in the evening.
Elderly
No dose adjustment is generally required for elderly patients with normal renal function. Dose should be adjusted in elderly patients with impaired renal function.
Renal_impairment
Dose adjustment is necessary for patients with impaired renal function. Consult a physician for specific dosage based on creatinine clearance.
How to Take
Take Lumona 10 mg Tablet orally with or without food, as directed by your physician. It is typically taken once daily in the evening.
Mechanism of Action
Levocetirizine selectively inhibits peripheral H1-receptors. By blocking the action of histamine, a chemical mediator of allergic reactions, it effectively reduces the symptoms of allergies without causing significant central nervous system depression.
Pharmacokinetics
Onset
Onset of action is typically within 1 hour.
Excretion
Approximately 85.4% of the dose is excreted in urine and 12.9% in feces, mainly as unchanged drug.
Half life
The plasma elimination half-life is approximately 7-10 hours in healthy adults.
Absorption
Rapidly and extensively absorbed after oral administration. Peak plasma concentrations are reached in approximately 0.9 hours.
Metabolism
Less than 14% of the dose is metabolized in the liver by oxidation. Primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, cetirizine, or any other piperazine derivative or to any of the excipients.
- Patients with end-stage renal disease (CrCl < 10 mL/min) and those undergoing hemodialysis.
- Infants and children less than 6 months of age.
Drug Interactions
Ritonavir
May increase plasma concentrations of levocetirizine.
Theophylline
Small decrease in levocetirizine clearance, but no dose adjustment is usually needed.
Alcohol and other CNS depressants
May increase central nervous system depression, leading to increased drowsiness or impaired performance.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and initial agitation followed by drowsiness in children. In case of overdose, symptomatic or supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Levocetirizine is excreted in human breast milk. Consult your doctor before using this medicine during pregnancy or breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, cetirizine, or any other piperazine derivative or to any of the excipients.
- Patients with end-stage renal disease (CrCl < 10 mL/min) and those undergoing hemodialysis.
- Infants and children less than 6 months of age.
Drug Interactions
Ritonavir
May increase plasma concentrations of levocetirizine.
Theophylline
Small decrease in levocetirizine clearance, but no dose adjustment is usually needed.
Alcohol and other CNS depressants
May increase central nervous system depression, leading to increased drowsiness or impaired performance.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and initial agitation followed by drowsiness in children. In case of overdose, symptomatic or supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Levocetirizine is excreted in human breast milk. Consult your doctor before using this medicine during pregnancy or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Pharmacies, hospitals, clinics
Approval Status
DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Levocetirizine has undergone extensive clinical trials demonstrating its efficacy and safety for the approved indications. These trials confirm its rapid onset of action and sustained symptom relief.
Lab Monitoring
- No routine laboratory monitoring is typically required. Renal function may be monitored in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients to avoid concurrent alcohol use.
- Consider dose adjustment in patients with renal impairment.
- Counsel patients on potential drowsiness and its implications for daily activities.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine.
- Be aware of potential drowsiness and its impact on driving or operating machinery.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Lumona 10 mg Tablet may cause drowsiness, dizziness, or impaired concentration. Exercise caution when driving or operating machinery, especially when initiating therapy or increasing the dose.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hydration.
- Manage stress, as it can sometimes worsen allergic symptoms.
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