Lupred
Generic Name
Prednisolone
Manufacturer
Amico Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lupred 005 eye drop | ৳ 180.00 | N/A |
Description
Overview of the medicine
Lupred contains Prednisolone, a synthetic corticosteroid. It is used to treat a wide range of inflammatory and autoimmune conditions by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Initial dosage varies widely based on condition, typically 5-60 mg daily in single or divided doses. Must be individualized and tapered.
Elderly
Consider lower initial doses and slower titration due to increased risk of side effects.
Renal_impairment
No specific dose adjustment required for renal impairment, but caution advised.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal irritation. Administer once daily in the morning or as directed by physician.
Mechanism of Action
Prednisolone works by binding to glucocorticoid receptors, leading to changes in gene expression. This results in broad anti-inflammatory and immunosuppressive effects, inhibiting the release of inflammatory mediators and modulating immune cell function.
Pharmacokinetics
Onset
Onset of action typically within 1-2 hours, but full therapeutic effect may take several hours to days.
Excretion
Excreted mainly in the urine, with a small amount in feces.
Half life
Plasma half-life: 2-4 hours; Biological half-life: 18-36 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Antidiabetic agents
May reduce the hypoglycemic effect; dose adjustment of antidiabetic drugs may be needed.
Diuretics (potassium-depleting)
Increased risk of hypokalemia.
CYP3A4 inducers (e.g., Rifampicin, Phenytoin)
May decrease prednisolone levels.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase prednisolone levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely to cause life-threatening effects. Chronic overdose can lead to signs of Cushing's syndrome. Treatment is symptomatic and supportive; gradual withdrawal is key.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to fetus. Prednisolone is excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Antidiabetic agents
May reduce the hypoglycemic effect; dose adjustment of antidiabetic drugs may be needed.
Diuretics (potassium-depleting)
Increased risk of hypokalemia.
CYP3A4 inducers (e.g., Rifampicin, Phenytoin)
May decrease prednisolone levels.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase prednisolone levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely to cause life-threatening effects. Chronic overdose can lead to signs of Cushing's syndrome. Treatment is symptomatic and supportive; gradual withdrawal is key.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to fetus. Prednisolone is excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved (DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory and autoimmune conditions.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Adrenal function tests
Doctor Notes
- Emphasize the importance of gradual tapering to prevent adrenal crisis.
- Monitor patients for signs of infection, blood glucose levels, and bone health during prolonged therapy.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as it may lead to withdrawal symptoms.
- Take with food to reduce stomach upset.
- Report any unusual side effects or worsening of your condition to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Prednisolone may cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Engage in regular, moderate exercise to maintain bone health.
- Avoid exposure to people with infections, especially chickenpox or measles.
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