Magalrat-Plus
Generic Name
magalrat-plus-480-mg-chewable-tablet
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| magalrat plus 480 mg chewable tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Magalrat-Plus 480 mg Chewable Tablet is a combination medicine containing Magaldrate and Simethicone. It is primarily used for the symptomatic treatment of acidity, heartburn, indigestion, gastritis, and relief from gas, bloating, and abdominal discomfort.
Uses & Indications
Dosage
Adults
Chew 1 to 2 tablets, 3 to 4 times daily, preferably between meals and at bedtime, or as directed by the physician.
Elderly
No specific dose adjustment is generally required, but caution should be exercised in elderly patients with renal impairment.
Renal_impairment
Use with caution in patients with severe renal impairment due to potential accumulation of aluminum and magnesium ions. Consult a physician for appropriate dosing.
How to Take
Tablets should be chewed thoroughly before swallowing. Do not swallow whole. It can be taken with or without water.
Mechanism of Action
Magaldrate, an antacid, works by neutralizing excess stomach acid, thereby reducing heartburn and indigestion. Simethicone, an anti-foaming agent, reduces the surface tension of gas bubbles in the gastrointestinal tract, causing them to coalesce and facilitating their easier expulsion, thus relieving bloating and flatulence.
Pharmacokinetics
Onset
Within 5-10 minutes (for acid neutralization)
Excretion
Magaldrate components (Magnesium and Aluminum) are excreted primarily in feces; Simethicone is excreted unchanged in feces.
Half life
Not applicable for Magaldrate (local action); Simethicone not absorbed.
Absorption
Magaldrate is minimally absorbed systemically. Simethicone is not absorbed from the gastrointestinal tract.
Metabolism
Not applicable; primarily local action in GI tract.
Side Effects
Contraindications
- Known hypersensitivity to Magaldrate, Simethicone, or any component of the formulation.
- Severe renal impairment (due to risk of magnesium and aluminum accumulation).
Drug Interactions
Digoxin
Reduced absorption of digoxin.
Iron Salts
Reduced absorption of iron.
Thyroid Hormones
Reduced absorption of levothyroxine.
Ketoconazole & Itraconazole
Reduced absorption due to increased gastric pH.
Tetracyclines & Fluoroquinolones
Reduced absorption due to chelation.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is rare due to the low systemic absorption. Symptoms may include severe constipation, diarrhea, abdominal pain, and in severe renal impairment, symptoms of hypermagnesemia (muscle weakness, hypotension) or aluminum toxicity (encephalopathy, osteomalacia). Treatment is supportive, including gastric lavage if recent, and management of electrolyte imbalances.
Pregnancy & Lactation
Pregnancy Category B. While generally considered safe, it should be used with caution during pregnancy and lactation only if clearly needed and under medical supervision. Consult your doctor.
Side Effects
Contraindications
- Known hypersensitivity to Magaldrate, Simethicone, or any component of the formulation.
- Severe renal impairment (due to risk of magnesium and aluminum accumulation).
Drug Interactions
Digoxin
Reduced absorption of digoxin.
Iron Salts
Reduced absorption of iron.
Thyroid Hormones
Reduced absorption of levothyroxine.
Ketoconazole & Itraconazole
Reduced absorption due to increased gastric pH.
Tetracyclines & Fluoroquinolones
Reduced absorption due to chelation.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is rare due to the low systemic absorption. Symptoms may include severe constipation, diarrhea, abdominal pain, and in severe renal impairment, symptoms of hypermagnesemia (muscle weakness, hypotension) or aluminum toxicity (encephalopathy, osteomalacia). Treatment is supportive, including gastric lavage if recent, and management of electrolyte imbalances.
Pregnancy & Lactation
Pregnancy Category B. While generally considered safe, it should be used with caution during pregnancy and lactation only if clearly needed and under medical supervision. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, check packaging for exact details.
Availability
Pharmacies, drugstores
Approval Status
DGDA Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical experience supports the efficacy and safety of Magaldrate and Simethicone combination as antacid and anti-flatulent. Specific trials for 'Magalrat-Plus' may exist, typically focusing on bioavailability or comparative studies.
Lab Monitoring
- Serum phosphate levels (with prolonged use)
- Renal function (in patients with renal impairment)
- Serum magnesium and aluminum levels (in high-risk patients)
Doctor Notes
- Advise patients on proper chewing technique.
- Counsel on potential drug interactions, especially with antibiotics and thyroid hormones.
- Monitor renal function in elderly or renally impaired patients on prolonged therapy.
- Distinguish between symptomatic relief and underlying disease requiring further investigation.
Patient Guidelines
- Chew the tablets thoroughly before swallowing.
- Do not exceed the recommended dose without consulting a doctor.
- If symptoms persist for more than 2 weeks, consult a physician.
- Separate doses from other medications by at least 2 hours.
- Drink plenty of water to help relieve constipation if it occurs.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Magalrat-Plus is generally not expected to impair the ability to drive or operate machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, or acidic foods.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Manage stress levels.
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Global Brand Names
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