Magalrat-Plus
Generic Name
Magnesium Hydroxide 480 mg + Aluminium Hydroxide 400 mg + Simethicone 30 mg / 10 mL Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| magalrat plus 480 mg suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Magalrat-Plus 480 mg Suspension is a combination antacid and antiflatulent used to relieve symptoms of heartburn, indigestion, sour stomach, and gas. It contains Aluminium Hydroxide and Magnesium Hydroxide to neutralize stomach acid, and Simethicone to break down gas bubbles.
Uses & Indications
Dosage
Adults
10-20 mL (2-4 teaspoonfuls) four times daily, between meals, at bedtime, or as directed by a physician.
Elderly
Same as adult dose, but caution in patients with renal impairment due to potential for magnesium accumulation.
Renal_impairment
Use with caution; dose adjustment may be necessary. Not recommended for severe renal impairment due to risk of hypermagnesemia.
How to Take
Shake the bottle well before each use. Take orally. It is generally recommended to take antacids between meals and at bedtime for maximum effect.
Mechanism of Action
Aluminium Hydroxide and Magnesium Hydroxide are antacids that react chemically with hydrochloric acid in the stomach to neutralize it, reducing acidity. Magnesium Hydroxide also acts as a laxative. Simethicone is an antiflatulent that reduces surface tension of gas bubbles in the gastrointestinal tract, causing them to coalesce and be more easily expelled.
Pharmacokinetics
Onset
Rapid (within minutes for acid neutralization)
Excretion
Unabsorbed magnesium and aluminium are excreted in feces. Absorbed magnesium is excreted renally.
Half life
Not applicable for unabsorbed components; absorbed magnesium has a renal elimination half-life.
Absorption
Magnesium Hydroxide and Aluminium Hydroxide are minimally absorbed systemically, though some magnesium ions may be absorbed, especially in renal impairment. Simethicone is not absorbed from the gastrointestinal tract.
Metabolism
Not applicable for unabsorbed components.
Side Effects
Contraindications
- Hypersensitivity to any component of the suspension.
- Severe renal impairment (risk of hypermagnesemia).
- Hypophosphatemia (with prolonged use of aluminium-containing antacids).
Drug Interactions
Bisphosphonates
Reduced absorption. Take bisphosphonates at least 30 minutes before antacids.
Thyroid hormones
May reduce absorption of levothyroxine. Separate administration times.
Iron salts & Digoxin
Reduced absorption when taken concurrently with antacids.
Mycophenolate Mofetil
Reduced absorption, avoid concurrent use.
Tetracyclines & Quinolones
Antacids can decrease the absorption of these antibiotics. Administer at least 2 hours before or 4-6 hours after antacids.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe diarrhea (magnesium), constipation (aluminium), and electrolyte imbalances. In severe cases of renal impairment, hypermagnesemia can occur, leading to hypotension, nausea, vomiting, central nervous system depression, and cardiac irregularities. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe for occasional use during pregnancy and lactation, but consult a doctor before use. Prolonged high-dose use is not recommended.
Side Effects
Contraindications
- Hypersensitivity to any component of the suspension.
- Severe renal impairment (risk of hypermagnesemia).
- Hypophosphatemia (with prolonged use of aluminium-containing antacids).
Drug Interactions
Bisphosphonates
Reduced absorption. Take bisphosphonates at least 30 minutes before antacids.
Thyroid hormones
May reduce absorption of levothyroxine. Separate administration times.
Iron salts & Digoxin
Reduced absorption when taken concurrently with antacids.
Mycophenolate Mofetil
Reduced absorption, avoid concurrent use.
Tetracyclines & Quinolones
Antacids can decrease the absorption of these antibiotics. Administer at least 2 hours before or 4-6 hours after antacids.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe diarrhea (magnesium), constipation (aluminium), and electrolyte imbalances. In severe cases of renal impairment, hypermagnesemia can occur, leading to hypotension, nausea, vomiting, central nervous system depression, and cardiac irregularities. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe for occasional use during pregnancy and lactation, but consult a doctor before use. Prolonged high-dose use is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date (check specific packaging for details)
Availability
Available in pharmacies and supermarkets
Approval Status
Approved (DGDA)
Patent Status
Generic available
Clinical Trials
As a well-established combination antacid, specific new clinical trials for its general efficacy are rare. Studies typically focus on formulation improvements or specific patient populations.
Lab Monitoring
- Serum magnesium levels (in patients with renal impairment)
- Serum phosphate levels (with prolonged high-dose use)
Doctor Notes
- Advise patients with renal impairment to use with caution and monitor magnesium levels.
- Educate patients on potential drug interactions, especially with antibiotics, iron, and thyroid hormones.
- Emphasize the importance of lifestyle modifications alongside medication for GERD/dyspepsia management.
- If symptoms persist or worsen despite regular use, investigate underlying causes.
Patient Guidelines
- Shake well before each use.
- Do not take more than the recommended dose.
- If symptoms persist for more than two weeks, consult your doctor.
- Separate administration from other medications by at least 2-4 hours.
- Store at room temperature away from light and moisture.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
This medicine is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger indigestion (e.g., spicy foods, caffeine, alcohol, fatty foods).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Maintain a healthy weight.
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