Magnolax
Generic Name
Magnesium Hydroxide + Liquid Paraffin + Sodium Picosulfate
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| magnolax 300 mg emulsion | ৳ 95.00 | N/A |
Description
Overview of the medicine
Magnolax is a combination laxative used for the short-term treatment of constipation, providing relief by increasing water in the intestine, softening stool, and stimulating bowel movements.
Uses & Indications
Dosage
Adults
Adults: 10-20 ml (2-4 teaspoonfuls) at bedtime or as directed by physician.
Elderly
Same as adult dose, but caution advised. Start with lower dose.
Renal_impairment
Use with caution in severe renal impairment due to magnesium content. Dose adjustment may be needed.
How to Take
Shake well before use. Take orally, preferably at bedtime for overnight relief.
Mechanism of Action
Magnesium Hydroxide acts as an osmotic laxative, drawing water into the intestine. Liquid Paraffin acts as a stool softener and lubricant. Sodium Picosulfate is a stimulant laxative that increases peristalsis.
Pharmacokinetics
Onset
2-8 hours (Sodium Picosulfate), 0.5-6 hours (Magnesium Hydroxide)
Excretion
Primarily fecal (unabsorbed portions); renal (minimally absorbed magnesium and picosulfate metabolites).
Half life
Not clinically significant for Magnesium Hydroxide and Liquid Paraffin; Sodium Picosulfate has a short half-life of its active metabolite.
Absorption
Magnesium Hydroxide is poorly absorbed; Liquid Paraffin is minimally absorbed; Sodium Picosulfate is absorbed minimally and activated in the colon.
Metabolism
Magnesium Hydroxide is not metabolized; Liquid Paraffin is not metabolized; Sodium Picosulfate is metabolized by colonic bacteria to its active form.
Side Effects
Contraindications
- •Hypersensitivity to any component
- •Acute abdominal pain, nausea, vomiting, or other symptoms of appendicitis
- •Intestinal obstruction
- •Undiagnosed rectal bleeding
- •Severe dehydration
Drug Interactions
Digoxin
May decrease digoxin absorption.
Diuretics
Increased risk of electrolyte imbalance, especially hypokalemia, with prolonged use.
Oral anticoagulants
Liquid paraffin may impair absorption of fat-soluble vitamins (A, D, E, K), potentially enhancing anticoagulant effect.
Tetracyclines/Quinolones
May decrease absorption of these antibiotics due to magnesium content. Administer 2-4 hours apart.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include severe diarrhea, abdominal cramps, dehydration, and electrolyte imbalance. Management involves supportive care, fluid and electrolyte replacement.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult a physician before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
Off-patent
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Global Brand Names
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