Maprocin DS
Generic Name
Naproxen
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maprocin ds 400 mg injection | ৳ 130.88 | N/A |
Description
Overview of the medicine
Maprocin DS contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is commonly prescribed for conditions like arthritis, gout, menstrual pain, and musculoskeletal disorders.
Uses & Indications
Dosage
Adults
For most conditions: 500 mg twice daily or 750 mg once daily. Max initial dose 1250 mg/day, then 1000 mg/day.
Elderly
Lower effective dose should be considered and closely monitored due to increased risk of adverse effects.
Renal_impairment
Use with caution and consider dose reduction in patients with mild to moderate renal impairment. Contraindicated in severe renal impairment.
How to Take
Take orally with a full glass of water, preferably with food or milk to minimize gastrointestinal irritation. Do not crush or chew tablets.
Mechanism of Action
Naproxen inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin production, naproxen effectively alleviates these symptoms.
Pharmacokinetics
Onset
Pain relief typically begins within 1 hour.
Excretion
Mainly excreted in the urine (approximately 95%) as unchanged drug and metabolites, with a small amount excreted in the feces.
Half life
The elimination half-life is approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-4 hours after oral administration.
Metabolism
Primarily metabolized in the liver by demethylation and glucuronidation to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs (manifested as asthma, urticaria, or allergic-type reactions)
- History of active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Congestive heart failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
SSRIs/SNRIs
Increased risk of gastrointestinal bleeding.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors, Angiotensin Receptor Blockers (ARBs), Diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, heartburn, nausea, vomiting, epigastric pain. More severe symptoms can include gastrointestinal bleeding, acute renal failure, hypertension, and respiratory depression. Management is primarily symptomatic and supportive. Gastric lavage and/or activated charcoal may be considered within 4 hours of ingestion.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to potential adverse effects on the fetal cardiovascular system (premature closure of the ductus arteriosus). Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Lactation: Naproxen is excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs (manifested as asthma, urticaria, or allergic-type reactions)
- History of active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Congestive heart failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
SSRIs/SNRIs
Increased risk of gastrointestinal bleeding.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors, Angiotensin Receptor Blockers (ARBs), Diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, heartburn, nausea, vomiting, epigastric pain. More severe symptoms can include gastrointestinal bleeding, acute renal failure, hypertension, and respiratory depression. Management is primarily symptomatic and supportive. Gastric lavage and/or activated charcoal may be considered within 4 hours of ingestion.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to potential adverse effects on the fetal cardiovascular system (premature closure of the ductus arteriosus). Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Lactation: Naproxen is excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Naproxen has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various pain and inflammatory conditions over decades. Ongoing research continues to explore its full therapeutic potential and optimize its use.
Lab Monitoring
- Complete Blood Count (CBC) with differential, especially during long-term therapy
- Liver Function Tests (LFTs)
- Kidney Function Tests (KFTs) including serum creatinine and BUN
- Blood pressure monitoring
Doctor Notes
- Advise patients to use the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Monitor patients for signs and symptoms of GI bleeding, cardiovascular events, and renal toxicity.
- Caution patients about potential drug interactions, especially with anticoagulants, corticosteroids, and ACE inhibitors.
Patient Guidelines
- Take the medication with food or milk to minimize stomach upset.
- Do not lie down for at least 10 minutes after taking the tablet.
- Report any signs of unusual bleeding, severe stomach pain, black or tarry stools, or swelling.
- Avoid concurrent use of other NSAIDs without consulting a doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Naproxen may cause dizziness or drowsiness in some individuals. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how the drug affects them.
Lifestyle Advice
- Avoid alcohol consumption as it may increase the risk of gastrointestinal side effects.
- Maintain a balanced diet and adequate hydration.
- Discuss any pre-existing medical conditions or other medications with your doctor before starting naproxen.
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