Marcus
Generic Name
Cinnarizine
Manufacturer
Unimed Unihealth Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| marcus 5 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Marcus 5 mg tablet contains Cinnarizine, an antihistamine and calcium channel blocker used to treat symptoms of vertigo, dizziness, and motion sickness. It also helps in conditions like Meniere's disease and cerebral vascular disorders.
Uses & Indications
Dosage
Adults
For vertigo/dizziness: 25 mg (five 5 mg tablets) three times daily. For motion sickness: 25 mg (five 5 mg tablets) 2 hours before travel, then 12.5 mg (two and a half 5 mg tablets) every 8 hours during travel. For cerebral vascular disorders: 75 mg (fifteen 5 mg tablets) daily in divided doses.
Elderly
Similar to adult dosage, but caution with lower initial dose due to increased susceptibility to side effects.
Renal_impairment
No specific dose adjustment required for mild to moderate renal impairment; use with caution in severe renal impairment.
How to Take
Marcus 5 mg tablet is for oral use. It should be taken with water, preferably after meals to minimize gastrointestinal irritation.
Mechanism of Action
Cinnarizine acts by blocking H1 histamine receptors, reducing vestibular excitability. It also inhibits calcium influx into vascular smooth muscle cells, leading to vasodilation and improved microcirculation, particularly in the cerebral vessels.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Approximately 2/3 excreted via feces and 1/3 via urine, primarily as metabolites.
Half life
Approximately 4 hours.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in 1-3 hours.
Metabolism
Extensively metabolized in the liver (mainly via CYP2D6).
Side Effects
Contraindications
- Hypersensitivity to Cinnarizine or any excipients of the tablet
- Parkinson's disease (may exacerbate symptoms)
- Acute porphyria
Drug Interactions
Hypotensive agents
May lead to additive hypotensive effects.
Anticholinergic drugs
Potentiation of anticholinergic effects.
CNS depressants (alcohol, sedatives, hypnotics)
Concurrent use may enhance the sedative effects of Cinnarizine.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, stupor, coma, ataxia, extrapyramidal symptoms, and hypotension. Management is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Cinnarizine should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. It may pass into breast milk; caution is advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Cinnarizine or any excipients of the tablet
- Parkinson's disease (may exacerbate symptoms)
- Acute porphyria
Drug Interactions
Hypotensive agents
May lead to additive hypotensive effects.
Anticholinergic drugs
Potentiation of anticholinergic effects.
CNS depressants (alcohol, sedatives, hypnotics)
Concurrent use may enhance the sedative effects of Cinnarizine.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, stupor, coma, ataxia, extrapyramidal symptoms, and hypotension. Management is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Cinnarizine should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. It may pass into breast milk; caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Clinical trials have demonstrated Cinnarizine's efficacy in managing symptoms of vertigo, dizziness, and motion sickness, showing a generally favorable safety profile at recommended doses.
Lab Monitoring
- Liver function tests (with prolonged high-dose use)
- Renal function (in patients with pre-existing kidney impairment)
Doctor Notes
- Caution advised in patients with Parkinson's disease, as Cinnarizine may worsen symptoms.
- Monitor for signs of depression, especially in elderly patients on long-term therapy.
- Administer after meals to reduce gastrointestinal side effects.
Patient Guidelines
- Do not exceed the recommended dosage.
- Avoid sudden discontinuation if used for a long duration without consulting a doctor.
- Report any severe or persistent side effects to your healthcare provider.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not double the dose to catch up.
Driving Precautions
Marcus 5 mg tablet may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Avoid driving or operating heavy machinery if you experience drowsiness or dizziness.
- Limit or avoid alcohol consumption while taking this medication.
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Global Brand Names
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