Marzev
Generic Name
Marzev 125 mg Tablet
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| marzev 125 mg tablet | ৳ 80.00 | ৳ 320.00 |
Description
Overview of the medicine
Marzev 125 mg Tablet is a medication primarily used for the management of hypertension (high blood pressure) and certain cardiovascular conditions. It works by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Initial dose 125 mg once daily. May be increased to 250 mg once daily after 7-14 days if needed for blood pressure control. Max dose: 500 mg daily.
Elderly
Consider lower initial dose (e.g., 62.5 mg once daily) and titrate slowly due to potential for increased sensitivity and reduced drug clearance.
Renal_impairment
No dose adjustment is typically required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally with or without food, preferably at the same time each day. Swallow the tablet whole; do not crush, chew, or break it.
Mechanism of Action
Marzev acts as a calcium channel blocker, specifically targeting L-type calcium channels. By inhibiting the influx of calcium ions into vascular smooth muscle cells and myocardial cells, it causes peripheral vasodilation, reduces systemic vascular resistance, and lowers blood pressure. It may also have anti-anginal effects by improving myocardial oxygen supply.
Pharmacokinetics
Onset
Onset of action within 30-60 minutes, peak plasma concentrations typically reached in 2-4 hours.
Excretion
Primarily excreted in urine (approx. 60-70%) as metabolites, with a smaller portion excreted in feces.
Half life
Terminal elimination half-life is approximately 10-15 hours, allowing for once-daily dosing.
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract; bioavailability is approximately 60-70% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 (CYP3A4) enzymes, into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Marzev or any component of the formulation
- Severe hypotension (systolic blood pressure <90 mmHg)
- Cardiogenic shock
- Severe aortic stenosis
Drug Interactions
Other Antihypertensives
Additive hypotensive effects may occur when co-administered with other blood pressure-lowering agents.
CYP3A4 Inducers (e.g., Rifampin, Phenytoin)
May decrease Marzev plasma concentrations, potentially reducing its therapeutic effect. Dose adjustment may be necessary.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Marzev plasma concentrations, leading to increased risk of adverse effects. Monitor blood pressure closely.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, bradycardia, dizziness, and collapse. Treatment is supportive, including intravenous fluids, vasopressors, and atropine if bradycardia is severe. Activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Marzev is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Marzev or any component of the formulation
- Severe hypotension (systolic blood pressure <90 mmHg)
- Cardiogenic shock
- Severe aortic stenosis
Drug Interactions
Other Antihypertensives
Additive hypotensive effects may occur when co-administered with other blood pressure-lowering agents.
CYP3A4 Inducers (e.g., Rifampin, Phenytoin)
May decrease Marzev plasma concentrations, potentially reducing its therapeutic effect. Dose adjustment may be necessary.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Marzev plasma concentrations, leading to increased risk of adverse effects. Monitor blood pressure closely.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, bradycardia, dizziness, and collapse. Treatment is supportive, including intravenous fluids, vasopressors, and atropine if bradycardia is severe. Activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Marzev is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated Marzev's efficacy in reducing blood pressure and improving exercise capacity in patients with hypertension and angina, respectively. Further trials are ongoing to evaluate its long-term cardiovascular outcomes.
Lab Monitoring
- Regular monitoring of blood pressure and heart rate.
- Liver function tests if symptoms of hepatic impairment develop.
Doctor Notes
- Advise patients on the importance of consistent medication adherence.
- Monitor for signs of peripheral edema and adjust diuretic therapy if necessary.
Patient Guidelines
- Take Marzev exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor, as it may worsen your condition.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Marzev may cause dizziness, especially at the start of treatment or when the dose is increased. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Adopt a healthy lifestyle, including a balanced diet low in sodium and saturated fats, regular exercise, and maintaining a healthy weight.
- Limit alcohol consumption and avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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