Marzev
Generic Name
Marzev-thiazide
Manufacturer
PharmaCo Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| marzev 25 mg tablet | ৳ 140.00 | ৳ 560.00 |
Description
Overview of the medicine
Marzev 25 mg Tablet is a diuretic medicine used to treat high blood pressure (hypertension) and edema caused by various conditions such as heart failure, kidney disease, or liver disease. It helps the body get rid of excess water and salt.
Uses & Indications
Dosage
Adults
For hypertension: 25 mg once daily, preferably in the morning. May be increased to 50 mg if necessary. For edema: 25-50 mg once or twice daily, or intermittently.
Elderly
Initiate with a lower dose (e.g., 12.5 mg) and titrate based on response and tolerability.
Renal_impairment
Use with caution. Not effective in severe renal impairment (creatinine clearance <30 mL/min). Lower doses may be required.
How to Take
Take Marzev 25 mg Tablet orally with or without food, preferably in the morning to avoid nocturnal diuresis. Swallow the tablet whole with water.
Mechanism of Action
Marzev-thiazide, a thiazide-like diuretic, acts primarily in the distal convoluted tubule of the kidney. It inhibits the sodium-chloride symporter, leading to increased excretion of sodium, chloride, and water, thereby reducing blood volume and blood pressure.
Pharmacokinetics
Onset
Diuretic effect: 2 hours; Antihypertensive effect: 2 hours.
Excretion
Primarily excreted unchanged by the kidneys (approximately 50-70% within 24 hours).
Half life
Approximately 6-15 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is moderate (50-60%).
Metabolism
Minimal hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to Marzev-thiazide or other sulfonamide-derived drugs
- Anuria (absence of urine production)
- Severe renal impairment
- Severe hepatic impairment
Drug Interactions
Lithium
Thiazides reduce renal clearance of lithium, increasing the risk of lithium toxicity.
Corticosteroids
Increased risk of electrolyte imbalance, particularly hypokalemia.
Antidiabetic drugs
Thiazides may decrease the glucose-lowering effect of antidiabetic agents, requiring dose adjustments.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the diuretic and antihypertensive effects of thiazides.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include electrolyte depletion (hypokalemia, hypochloremia, hyponatremia), dehydration, hypotension, and dizziness. Management involves symptomatic and supportive treatment, including correction of fluid and electrolyte imbalance. Gastric lavage or activated charcoal may be considered in recent ingestions.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed, as it crosses the placental barrier. Not recommended during lactation as it is excreted in breast milk and may suppress lactation. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Marzev-thiazide or other sulfonamide-derived drugs
- Anuria (absence of urine production)
- Severe renal impairment
- Severe hepatic impairment
Drug Interactions
Lithium
Thiazides reduce renal clearance of lithium, increasing the risk of lithium toxicity.
Corticosteroids
Increased risk of electrolyte imbalance, particularly hypokalemia.
Antidiabetic drugs
Thiazides may decrease the glucose-lowering effect of antidiabetic agents, requiring dose adjustments.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the diuretic and antihypertensive effects of thiazides.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include electrolyte depletion (hypokalemia, hypochloremia, hyponatremia), dehydration, hypotension, and dizziness. Management involves symptomatic and supportive treatment, including correction of fluid and electrolyte imbalance. Gastric lavage or activated charcoal may be considered in recent ingestions.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed, as it crosses the placental barrier. Not recommended during lactation as it is excreted in breast milk and may suppress lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Marzev-thiazide has undergone standard clinical trials demonstrating its efficacy and safety in managing hypertension and edema. Studies have shown comparable efficacy to other established thiazide diuretics.
Lab Monitoring
- Serum electrolytes (potassium, sodium, chloride)
- Renal function (BUN, creatinine)
- Blood glucose levels
- Liver function tests (if underlying liver disease)
Doctor Notes
- Monitor serum electrolytes (especially potassium) and renal function regularly, particularly in elderly patients and those on concomitant medications.
- Caution in patients with diabetes mellitus due to potential for hyperglycemia.
- Advise patients on symptoms of hypokalemia (e.g., muscle weakness, palpitations).
Patient Guidelines
- Take medicine exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor.
- Monitor your blood pressure regularly at home if advised.
- Report any unusual side effects, especially dizziness or muscle weakness, to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Marzev 25 mg Tablet may cause dizziness, especially when starting treatment or changing dose. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Follow a low-sodium diet to enhance the effect of the medicine.
- Stay adequately hydrated, but avoid excessive fluid intake without medical advice.
- Engage in regular physical activity as advised by your doctor.
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Global Brand Names
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