Maxidim 500 mg Injection is administered intravenously (IV) via slow infusion (over 30-60 minutes) or intramuscularly (IM) via deep injection. The powder must be reconstituted with an appropriate diluent (e.g., sterile water for injection) before use.

Cefepime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby interfering with the transpeptidation step of peptidoglycan synthesis. This leads to the disruption of the cell wall, ultimately resulting in bacterial cell lysis and death.

• •Hypersensitivity to Cefepime, other cephalosporins, penicillins, or any component of the formulation.
• •History of immediate and severe hypersensitivity reactions to any beta-lactam antibiotic.

Store unopened vials at room temperature (below 25°C), protected from light. After reconstitution, the solution should be used immediately or stored under refrigeration (2-8°C) for a limited period as per manufacturer guidelines.

In cases of severe overdose, symptoms may include encephalopathy, seizures, myoclonus, and neuromuscular excitability. Management should be supportive. Hemodialysis is effective in removing cefepime from the body and may be beneficial in severe overdose with renal impairment.

Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use during pregnancy only if clearly needed. Cefepime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.