Maxilax
Generic Name
Polyethylene Glycol 3350 (Macrogol 3350)
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxilax 10 gm oral solution | ৳ 65.00 | N/A |
Description
Overview of the medicine
Maxilax 10 gm Oral Solution contains Polyethylene Glycol 3350, an osmotic laxative used for the symptomatic treatment of constipation in adults and children aged 8 years and above.
Uses & Indications
Dosage
Adults
1-2 sachets (10-20 gm) daily, preferably in the morning. Adjust dose according to response.
Elderly
Same as adult dosage, but start with lower dose if sensitive. Adjust dose according to response.
Renal_impairment
No dose adjustment required.
How to Take
Dissolve the contents of one sachet in about 125 ml (half a glass) of water and drink. Take preferably in the morning. Do not exceed the recommended dose.
Mechanism of Action
Polyethylene Glycol 3350 acts by retaining water in the colon, thereby increasing stool volume and softening the feces. This facilitates easier bowel movements and alleviates constipation.
Pharmacokinetics
Onset
Onset of action typically occurs within 24-48 hours.
Excretion
Excreted unchanged in the feces.
Half life
Not determined due to minimal systemic absorption; excreted primarily unchanged.
Absorption
Poorly absorbed from the gastrointestinal tract (less than 1% absorbed).
Metabolism
Not metabolized by the body or intestinal flora.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Severe inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease).
- Toxic megacolon.
- Intestinal perforation or risk of intestinal perforation.
- Intestinal obstruction or suspicion of intestinal obstruction.
- Abdominal pain of unknown origin.
Drug Interactions
Other laxatives
Concurrent use with other laxatives is generally not recommended as it may exacerbate side effects.
Medications requiring precise absorption
PEG 3350 may temporarily reduce the absorption of other orally administered medications if taken simultaneously. It is advisable to take other medications at least 1 hour before or several hours after Maxilax.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe diarrhea, abdominal pain, and dehydration. Management involves symptomatic treatment, electrolyte correction, and fluid replacement.
Pregnancy & Lactation
Maxilax can be used during pregnancy and lactation if necessary, as systemic absorption is negligible. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Severe inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease).
- Toxic megacolon.
- Intestinal perforation or risk of intestinal perforation.
- Intestinal obstruction or suspicion of intestinal obstruction.
- Abdominal pain of unknown origin.
Drug Interactions
Other laxatives
Concurrent use with other laxatives is generally not recommended as it may exacerbate side effects.
Medications requiring precise absorption
PEG 3350 may temporarily reduce the absorption of other orally administered medications if taken simultaneously. It is advisable to take other medications at least 1 hour before or several hours after Maxilax.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe diarrhea, abdominal pain, and dehydration. Management involves symptomatic treatment, electrolyte correction, and fluid replacement.
Pregnancy & Lactation
Maxilax can be used during pregnancy and lactation if necessary, as systemic absorption is negligible. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on specific formulation and packaging.
Availability
Pharmacies, drugstores
Approval Status
Approved by health authorities worldwide
Patent Status
Generic available (off-patent)
Clinical Trials
Extensive clinical trials have confirmed the efficacy and safety of Polyethylene Glycol 3350 for chronic constipation across various age groups. Studies demonstrate its ability to increase stool frequency and improve stool consistency without significant electrolyte disturbances.
Lab Monitoring
- Not routinely required.
- In cases of prolonged use or electrolyte imbalance suspicion, electrolytes might be monitored.
Doctor Notes
- Advise patients on adequate hydration.
- Rule out organic causes of constipation before prescribing.
- Monitor for signs of electrolyte imbalance in susceptible patients.
Patient Guidelines
- Ensure adequate fluid intake during treatment.
- Do not use for more than 2 weeks without medical advice.
- If constipation persists, consult a doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Maxilax has no known effect on the ability to drive or use machines.
Lifestyle Advice
- Maintain a high-fiber diet.
- Drink plenty of water.
- Engage in regular physical activity.
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Global Brand Names
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