Maxsulin-N
Generic Name
Insulin Isophane (NPH) 100 IU/ml
Manufacturer
Max Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxsulin n 100 iu injection | ৳ 222.00 | N/A |
Description
Overview of the medicine
Maxsulin-N 100 IU Injection contains Insulin Isophane (NPH), an intermediate-acting human insulin used to control high blood sugar in people with type 1 and type 2 diabetes mellitus. It helps the body use sugar for energy and reduces glucose production in the liver.
Uses & Indications
Dosage
Adults
Individualized dosage based on patient's metabolic needs, blood glucose levels, and HbA1c. Typically, 0.5-1 unit/kg/day, often divided into two or more injections daily.
Elderly
Dose may need to be adjusted downwards due to decreased renal function and potential increased sensitivity to insulin. Regular monitoring of glucose is essential.
Renal_impairment
Dose reduction is often required due to decreased insulin clearance. Careful monitoring of blood glucose is necessary.
How to Take
Administer by subcutaneous injection into the abdomen, thigh, or upper arm. Rotate injection sites to prevent lipodystrophy. Do not inject intravenously or intramuscularly. Maxsulin-N should be given 30-45 minutes before a meal.
Mechanism of Action
Insulin isophane works by binding to insulin receptors on cells, primarily in muscle and fat tissue, to promote glucose uptake from the blood. It also inhibits hepatic glucose production and lipolysis, leading to a reduction in blood glucose levels.
Pharmacokinetics
Onset
1-2 hours
Excretion
Excreted primarily via the kidneys.
Half life
Functional half-life is variable due to prolonged absorption, but pharmacological effects last 18-24 hours.
Absorption
After subcutaneous injection, absorption is slower and more prolonged due to protamination, providing intermediate action. Absorption rate varies with injection site, dose, and blood flow.
Metabolism
Degraded by insulin-degrading enzymes (IDE) primarily in the liver and kidney.
Side Effects
Contraindications
- Hypersensitivity to insulin or any of the excipients
- Episodes of hypoglycemia
Drug Interactions
Oral antidiabetic agents, ACE inhibitors, salicylates, MAOIs, beta-blockers, alcohol
May increase the insulin's blood glucose-lowering effect.
Corticosteroids, danazol, diuretics, sympathomimetics, growth hormone, thyroid hormones
May reduce the insulin's blood glucose-lowering effect.
Storage
Unopened vials/cartridges should be stored in a refrigerator (2°C-8°C). Do not freeze. Opened vials/cartridges can be stored at room temperature (below 30°C) for up to 28 days. Protect from light and excessive heat.
Overdose
Overdose can lead to hypoglycemia. Mild hypoglycemia can be treated by oral glucose. Severe hypoglycemia (unconsciousness) requires glucagon injection or intravenous glucose. Seek immediate medical attention.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy and is considered safe. Dosage adjustments may be required throughout pregnancy and lactation. Insulin does not pass into breast milk in clinically significant amounts.
Side Effects
Contraindications
- Hypersensitivity to insulin or any of the excipients
- Episodes of hypoglycemia
Drug Interactions
Oral antidiabetic agents, ACE inhibitors, salicylates, MAOIs, beta-blockers, alcohol
May increase the insulin's blood glucose-lowering effect.
Corticosteroids, danazol, diuretics, sympathomimetics, growth hormone, thyroid hormones
May reduce the insulin's blood glucose-lowering effect.
Storage
Unopened vials/cartridges should be stored in a refrigerator (2°C-8°C). Do not freeze. Opened vials/cartridges can be stored at room temperature (below 30°C) for up to 28 days. Protect from light and excessive heat.
Overdose
Overdose can lead to hypoglycemia. Mild hypoglycemia can be treated by oral glucose. Severe hypoglycemia (unconsciousness) requires glucagon injection or intravenous glucose. Seek immediate medical attention.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy and is considered safe. Dosage adjustments may be required throughout pregnancy and lactation. Insulin does not pass into breast milk in clinically significant amounts.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 2-3 years when stored refrigerated. Opened: 28 days at room temperature (below 30°C).
Availability
Available in pharmacies and hospitals
Approval Status
DGDA approved
Patent Status
Off-patent (Generic)
WHO Essential Medicine
YesClinical Trials
Human NPH insulin has been extensively studied and used clinically for many decades, establishing its efficacy and safety profile.
Lab Monitoring
- Blood glucose levels (fasting, post-prandial)
- HbA1c (Glycated Hemoglobin) quarterly
- Renal function (e.g., creatinine) periodically
Doctor Notes
- Emphasize patient education on proper insulin administration, storage, and recognition/management of hypoglycemia.
- Stress the importance of consistent blood glucose monitoring and adherence to prescribed dosage.
- Advise patients on lifestyle modifications (diet, exercise) to optimize glycemic control.
Patient Guidelines
- Learn and follow proper injection technique, including site rotation.
- Monitor blood glucose levels regularly as advised by your doctor.
- Recognize the symptoms of hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar).
- Always carry a source of fast-acting sugar to treat mild hypoglycemia.
- Never share needles or insulin pens.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. Monitor blood glucose closely.
Driving Precautions
Patients should be advised of the risk of hypoglycemia and its impact on the ability to drive or operate machinery. Take precautions to avoid hypoglycemia while driving.
Lifestyle Advice
- Maintain a balanced diet with consistent carbohydrate intake.
- Engage in regular physical activity.
- Manage weight to improve insulin sensitivity.
- Avoid smoking.
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