Maxsulin-N
Generic Name
Insulin Isophane (NPH) human 40 IU/ml injection
Manufacturer
XYZ Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxsulin n 40 iu injection | ৳ 195.00 | N/A |
Description
Overview of the medicine
Maxsulin-N 40 IU Injection contains human isophane insulin (NPH insulin), an intermediate-acting insulin used to control high blood sugar levels in people with type 1 and type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
Individualized based on patient's blood glucose levels, diet, exercise, and lifestyle. Typically administered once or twice daily via subcutaneous injection.
Elderly
May require lower doses due to decreased renal function and increased sensitivity to insulin. Close monitoring of blood glucose is recommended.
Renal_impairment
Dosage adjustments may be necessary due to reduced insulin clearance. Close monitoring of blood glucose is essential.
How to Take
Administered subcutaneously into the thigh, abdomen, upper arm, or buttock. Rotate injection sites to prevent lipodystrophy. Do not administer intravenously.
Mechanism of Action
Insulin lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis in adipocytes, inhibits proteolysis, and enhances protein synthesis.
Pharmacokinetics
Onset
1.5 to 4 hours
Excretion
Mainly renal excretion of inactive metabolites.
Half life
Variable, depends on absorption rate; effectively refers to duration of action rather than a specific plasma half-life.
Absorption
After subcutaneous injection, NPH insulin is absorbed more slowly due to the presence of protamine, which forms a less soluble complex with insulin.
Metabolism
Insulin is primarily metabolized by insulinases in the liver and kidney.
Side Effects
Contraindications
- Hypoglycemia (low blood sugar)
- Hypersensitivity to insulin or any excipients
Drug Interactions
Corticosteroids, danazol, diuretics, thyroid hormones, sympathomimetics (e.g., epinephrine), growth hormone
May reduce insulin's glucose-lowering effect, requiring increased insulin dosage.
Oral antidiabetic agents, salicylates, sulfonamide antibiotics, certain antidepressants (MAOIs, SSRIs), beta-blockers, ACE inhibitors, alcohol
May increase insulin's glucose-lowering effect, increasing risk of hypoglycemia.
Storage
Unopened: Store in a refrigerator (2°C-8°C). Do not freeze. Protect from light. Opened: May be stored at room temperature (below 25°C) for up to 28 days. Do not refrigerate opened vials.
Overdose
Overdose of insulin can lead to severe hypoglycemia. Management involves oral glucose (for mild hypoglycemia) or intravenous glucose/glucagon (for severe hypoglycemia).
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy. Dosage requirements may change during pregnancy and lactation. Close monitoring is essential.
Side Effects
Contraindications
- Hypoglycemia (low blood sugar)
- Hypersensitivity to insulin or any excipients
Drug Interactions
Corticosteroids, danazol, diuretics, thyroid hormones, sympathomimetics (e.g., epinephrine), growth hormone
May reduce insulin's glucose-lowering effect, requiring increased insulin dosage.
Oral antidiabetic agents, salicylates, sulfonamide antibiotics, certain antidepressants (MAOIs, SSRIs), beta-blockers, ACE inhibitors, alcohol
May increase insulin's glucose-lowering effect, increasing risk of hypoglycemia.
Storage
Unopened: Store in a refrigerator (2°C-8°C). Do not freeze. Protect from light. Opened: May be stored at room temperature (below 25°C) for up to 28 days. Do not refrigerate opened vials.
Overdose
Overdose of insulin can lead to severe hypoglycemia. Management involves oral glucose (for mild hypoglycemia) or intravenous glucose/glucagon (for severe hypoglycemia).
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy. Dosage requirements may change during pregnancy and lactation. Close monitoring is essential.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unopened vials when stored correctly. Refer to the product leaflet for exact shelf life.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Human NPH insulin has been extensively studied for decades. Current trials usually focus on new formulations or combination therapies rather than basic NPH insulin.
Lab Monitoring
- Blood glucose levels (fasting, postprandial, HbA1c)
- Renal function
- Lipid profile
- Potassium levels (especially with concurrent potassium-lowering drugs)
Doctor Notes
- Educate patients thoroughly on insulin administration, hypoglycemia recognition/management, and sick day rules.
- Emphasize the importance of consistent monitoring and adherence to lifestyle modifications.
Patient Guidelines
- Always check the insulin type and strength before injection.
- Never share needles or insulin pens.
- Learn proper injection technique and site rotation.
Missed Dose Advice
If a dose is missed, check blood glucose and consult a doctor for advice. Do not take a double dose to compensate.
Driving Precautions
Patients should be advised about the risk of hypoglycemia and its impact on the ability to drive or operate machinery. Check blood glucose before driving, especially if prone to hypoglycemia.
Lifestyle Advice
- Maintain a consistent meal plan
- Exercise regularly
- Monitor blood glucose levels diligently
- Carry a source of fast-acting glucose for hypoglycemia
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Global Brand Names
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