Maxsulin-R
Generic Name
Human Insulin (Recombinant) 100 IU/ml
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxsulin r 100 iu injection | ৳ 415.00 | N/A |
Description
Overview of the medicine
Maxsulin-R 100 IU Injection is a fast-acting insulin used to improve blood sugar control in adults and children with diabetes mellitus. It helps the body utilize glucose for energy, thereby lowering blood sugar levels. It is typically administered before meals.
Uses & Indications
Dosage
Adults
Individualized based on patient's metabolic needs, blood glucose monitoring, and HbA1c. Typically administered subcutaneously 30-45 minutes before meals. Initial dosage often 0.3-0.8 IU/kg/day, divided into multiple injections.
Elderly
Close monitoring of blood glucose is recommended due to potential for increased sensitivity to insulin and higher risk of hypoglycemia. Dosage adjustments may be necessary.
Renal_impairment
Dosage reduction may be required due to decreased insulin clearance and increased risk of hypoglycemia. Careful monitoring of blood glucose levels is essential.
How to Take
Administer subcutaneously (under the skin) into the abdomen, thigh, or upper arm 30-45 minutes before a meal. Rotate injection sites to prevent lipodystrophy. Do not inject intravenously or intramuscularly unless specifically directed by a healthcare professional (e.g., for DKA intravenously).
Mechanism of Action
Human insulin binds to insulin receptors on cells (e.g., muscle, adipose tissue), facilitating glucose uptake from the blood, promoting glycogen synthesis in the liver and muscle, and inhibiting hepatic glucose production, thereby lowering blood glucose.
Pharmacokinetics
Onset
30 minutes (subcutaneous)
Excretion
Mainly excreted by the kidneys after metabolic breakdown.
Half life
Approximately 5-10 minutes in plasma, but biological half-life is longer due to tissue binding.
Absorption
Rapidly absorbed after subcutaneous injection. Absorption rate can be influenced by injection site, physical activity, and blood flow.
Metabolism
Primarily metabolized by insulinase in the liver and kidneys.
Side Effects
Contraindications
- Hypoglycemia (low blood sugar)
- Hypersensitivity to human insulin or any of its excipients
Drug Interactions
Alcohol
Can potentiate the hypoglycemic effect of insulin.
Beta-blockers
Can mask symptoms of hypoglycemia and delay recovery from hypoglycemia.
Oral antidiabetic agents
Increased risk of hypoglycemia.
Corticosteroids, Diuretics, Sympathomimetics
May reduce the hypoglycemic effect of insulin, requiring increased insulin dose.
Storage
Store unopened vials/pens in a refrigerator (2°C-8°C). Do not freeze. Protect from light. Once opened, store at room temperature (below 30°C) for up to 28 days. Do not refrigerate opened vials/pens.
Overdose
Overdose can lead to severe hypoglycemia. Mild hypoglycemia can be treated with oral glucose. Severe hypoglycemia requires glucagon injection or intravenous glucose administration by a healthcare professional.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes during pregnancy. Dosage requirements may change during pregnancy and lactation. Consult a doctor for adjustments. Insulin does not pass into breast milk.
Side Effects
Contraindications
- Hypoglycemia (low blood sugar)
- Hypersensitivity to human insulin or any of its excipients
Drug Interactions
Alcohol
Can potentiate the hypoglycemic effect of insulin.
Beta-blockers
Can mask symptoms of hypoglycemia and delay recovery from hypoglycemia.
Oral antidiabetic agents
Increased risk of hypoglycemia.
Corticosteroids, Diuretics, Sympathomimetics
May reduce the hypoglycemic effect of insulin, requiring increased insulin dose.
Storage
Store unopened vials/pens in a refrigerator (2°C-8°C). Do not freeze. Protect from light. Once opened, store at room temperature (below 30°C) for up to 28 days. Do not refrigerate opened vials/pens.
Overdose
Overdose can lead to severe hypoglycemia. Mild hypoglycemia can be treated with oral glucose. Severe hypoglycemia requires glucagon injection or intravenous glucose administration by a healthcare professional.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes during pregnancy. Dosage requirements may change during pregnancy and lactation. Consult a doctor for adjustments. Insulin does not pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (unopened, refrigerated). 28 days (opened, room temperature).
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patents expired, generic versions available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for efficacy and safety in Type 1 and Type 2 diabetes. Ongoing studies may focus on new delivery methods or combination therapies.
Lab Monitoring
- Blood glucose levels (fasting, pre-meal, post-meal, bedtime)
- HbA1c (every 3-6 months)
- Kidney function tests (creatinine, GFR)
- Liver function tests
- Electrolytes (potassium)
Doctor Notes
- Educate patients on proper injection technique and storage.
- Emphasize the importance of blood glucose monitoring and timely meal intake.
- Advise patients on recognizing and managing hypoglycemia.
Patient Guidelines
- Always check the insulin type and strength before injection.
- Rotate injection sites to prevent skin problems.
- Monitor blood glucose regularly as instructed by your doctor.
- Carry a source of fast-acting carbohydrate (e.g., glucose tablets, fruit juice) to treat mild hypoglycemia.
- Never share insulin pens, even if the needle is changed.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember, but only if it's close to your next meal. If it's too close to the next scheduled dose or if you are not planning to eat, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Patients should be advised to take precautions to avoid hypoglycemia while driving, especially if they experience recurrent hypoglycemia or diminished warning symptoms. Drive only when blood sugar is stable and not dropping.
Lifestyle Advice
- Maintain a balanced diet and follow a meal plan consistent with your diabetes management.
- Engage in regular physical activity as advised by your doctor.
- Avoid excessive alcohol consumption.
- Manage stress effectively to help control blood sugar.
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