Maxsulin-R
Generic Name
Human Insulin (Recombinant) 40 IU/ml
Manufacturer
Max Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxsulin r 40 iu injection | ৳ 195.00 | N/A |
Description
Overview of the medicine
Maxsulin-R is a brand of human insulin (recombinant DNA origin), a short-acting insulin used to improve blood sugar control in adults and children with diabetes mellitus. It helps the body use sugar for energy and lowers high blood sugar levels.
Uses & Indications
Dosage
Adults
Individualized. Typically administered subcutaneously 15-30 minutes before a meal. Initial dosage might be 0.3-0.8 IU/kg/day, divided into multiple injections. Dosage adjusted based on blood glucose levels.
Elderly
No specific dose reduction required, but careful monitoring of blood glucose is advised due to increased risk of hypoglycemia and renal impairment.
Renal_impairment
Dosage may need to be reduced due to decreased insulin clearance. Close monitoring of blood glucose is essential.
How to Take
Administer Maxsulin-R subcutaneously into the abdomen, thigh, upper arm, or buttock. Rotate injection sites within the same region to reduce the risk of lipodystrophy. Administer 15-30 minutes before a meal. Do not inject intravenously unless in an emergency clinical setting.
Mechanism of Action
Maxsulin-R is a short-acting insulin that lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.
Pharmacokinetics
Onset
30-60 minutes.
Excretion
Mainly excreted by the kidneys.
Half life
Approximately 1.5-2 hours in circulation, but the duration of action is longer due to slow absorption from the injection site.
Absorption
Rapidly absorbed following subcutaneous injection; peak concentrations usually reached within 1-3 hours.
Metabolism
Primarily degraded by insulinase in the liver, kidneys, and muscle.
Side Effects
Contraindications
- Hypersensitivity to human insulin or any of its excipients
- Hypoglycemia
Drug Interactions
Beta-blockers, Clonidine, Lithium salts, Alcohol
May either potentiate or weaken the blood glucose-lowering effect of insulin. Beta-blockers can also mask symptoms of hypoglycemia.
Oral Antidiabetics, ACE Inhibitors, Disopyramide, Fibrates, MAOIs, Propxyphene, Salicylates, Somatostatin analogs, Sulfonamide antibiotics
May enhance the glucose-lowering effect, increasing the risk of hypoglycemia.
Corticosteroids, Danazol, Diuretics, Sympathomimetics, Glucagon, Isoniazid, Phenothiazine derivatives, Somatropin, Thyroid hormones, Estrogens and Progestogens (e.g., in oral contraceptives)
May reduce the glucose-lowering effect, requiring increased insulin dosage.
Storage
Store unopened vials/cartridges in a refrigerator (2-8°C). Do not freeze. Protect from light. Once opened or in use, store at room temperature (up to 25-30°C) for up to 28 days, protected from direct heat and light.
Overdose
Overdose of insulin can lead to severe hypoglycemia. Symptoms include sweating, palpitation, tremor, hunger, confusion, dizziness, and in severe cases, unconsciousness and seizures. Management involves immediate oral glucose intake for conscious patients or intravenous glucose/glucagon for unconscious patients.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy. Dosage requirements usually decrease in the first trimester and increase in the second and third trimesters. It is safe for use during lactation, as insulin is excreted in breast milk in negligible amounts and is not absorbed orally by the infant.
Side Effects
Contraindications
- Hypersensitivity to human insulin or any of its excipients
- Hypoglycemia
Drug Interactions
Beta-blockers, Clonidine, Lithium salts, Alcohol
May either potentiate or weaken the blood glucose-lowering effect of insulin. Beta-blockers can also mask symptoms of hypoglycemia.
Oral Antidiabetics, ACE Inhibitors, Disopyramide, Fibrates, MAOIs, Propxyphene, Salicylates, Somatostatin analogs, Sulfonamide antibiotics
May enhance the glucose-lowering effect, increasing the risk of hypoglycemia.
Corticosteroids, Danazol, Diuretics, Sympathomimetics, Glucagon, Isoniazid, Phenothiazine derivatives, Somatropin, Thyroid hormones, Estrogens and Progestogens (e.g., in oral contraceptives)
May reduce the glucose-lowering effect, requiring increased insulin dosage.
Storage
Store unopened vials/cartridges in a refrigerator (2-8°C). Do not freeze. Protect from light. Once opened or in use, store at room temperature (up to 25-30°C) for up to 28 days, protected from direct heat and light.
Overdose
Overdose of insulin can lead to severe hypoglycemia. Symptoms include sweating, palpitation, tremor, hunger, confusion, dizziness, and in severe cases, unconsciousness and seizures. Management involves immediate oral glucose intake for conscious patients or intravenous glucose/glucagon for unconscious patients.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy. Dosage requirements usually decrease in the first trimester and increase in the second and third trimesters. It is safe for use during lactation, as insulin is excreted in breast milk in negligible amounts and is not absorbed orally by the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 2-3 years when stored correctly. Opened/In-use: 28 days.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Patent expired for human insulin
WHO Essential Medicine
YesClinical Trials
Human insulin has been extensively studied in numerous clinical trials since its introduction, demonstrating its efficacy and safety in managing diabetes mellitus across various patient populations.
Lab Monitoring
- Fasting Blood Glucose
- Postprandial Blood Glucose
- HbA1c (Glycated Hemoglobin)
- Kidney function tests (especially in patients with renal impairment)
- Liver function tests (periodically)
Doctor Notes
- Emphasize patient education on hypoglycemia recognition and management.
- Advise strict adherence to blood glucose monitoring and dietary recommendations.
- Review injection technique and rotation sites regularly.
Patient Guidelines
- Always check the insulin label carefully before each injection to avoid medication errors.
- Learn proper injection technique and rotate injection sites.
- Monitor blood glucose regularly as advised by your doctor.
- Carry a source of fast-acting carbohydrate (e.g., glucose tablets, fruit juice) to treat hypoglycemia.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, but only if it's still before your next meal. If it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Patients should be advised to take precautions to avoid hypoglycemia while driving, especially if prone to hypoglycemic episodes or if the ability to recognize hypoglycemia symptoms is reduced. Carry a rapid-acting sugar source.
Lifestyle Advice
- Maintain a consistent meal plan and carbohydrate intake.
- Engage in regular physical activity as advised by your healthcare provider.
- Avoid or limit alcohol consumption.
- Maintain a healthy weight.
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