Mebrex
Generic Name
Mebeverine
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mebrex 100 mg chewable tablet | ৳ 0.74 | N/A |
Description
Overview of the medicine
Mebeverine is an antispasmodic agent that directly acts on the smooth muscle of the gastrointestinal tract, relieving cramps and discomfort. It is used to treat symptoms of Irritable Bowel Syndrome (IBS) and other functional bowel disorders.
Uses & Indications
Dosage
Adults
100-200 mg three times daily, preferably 20 minutes before meals.
Elderly
No specific dosage adjustment required, but caution is advised.
Renal_impairment
No specific dosage adjustment required, but caution is advised in severe impairment.
How to Take
Chew the tablet thoroughly before swallowing. Take preferably 20 minutes before meals.
Mechanism of Action
Mebeverine directly acts on the smooth muscle of the gastrointestinal tract, primarily in the colon, without affecting normal gut motility. It is thought to reduce muscle spasms by blocking calcium channels in smooth muscle cells, leading to muscle relaxation and relief from cramps.
Pharmacokinetics
Onset
Effects usually seen within 1 hour.
Excretion
Metabolites are primarily excreted in the urine.
Half life
Short, approximately 2.4 hours for the main metabolite.
Absorption
Rapidly and completely absorbed after oral administration.
Metabolism
Extensively metabolized, primarily by esterases, into inactive metabolites (mebeverine alcohol and veratric acid).
Side Effects
Contraindications
- Hypersensitivity to mebeverine or any excipients.
- Paralytic ileus.
- Children under 2 years of age.
Drug Interactions
No significant interactions
No significant drug interactions have been reported.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS excitability. Management is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Use with caution during pregnancy only if clearly needed and the benefit outweighs the potential risk. Excretion into breast milk is unknown, so caution is advised.
Side Effects
Contraindications
- Hypersensitivity to mebeverine or any excipients.
- Paralytic ileus.
- Children under 2 years of age.
Drug Interactions
No significant interactions
No significant drug interactions have been reported.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS excitability. Management is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Use with caution during pregnancy only if clearly needed and the benefit outweighs the potential risk. Excretion into breast milk is unknown, so caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have confirmed the efficacy and safety of mebeverine in treating IBS.
Lab Monitoring
- Not typically required
Doctor Notes
- Advise patients on lifestyle modifications for IBS.
- Monitor patient response and adjust dosage as needed.
Patient Guidelines
- Take as directed by your doctor.
- Chew the tablet completely before swallowing.
- Inform your doctor if symptoms persist or worsen.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Mebrex is unlikely to affect the ability to drive or operate machinery. However, if you experience dizziness, avoid driving.
Lifestyle Advice
- Maintain a balanced diet rich in fiber.
- Stay hydrated.
- Manage stress.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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