Mecol
Generic Name
Methylcobalamin
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mecol 500 mcg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Mecol is a form of Vitamin B12 (Methylcobalamin) used to treat and prevent Vitamin B12 deficiency and associated conditions such as various forms of neuropathy.
Uses & Indications
Dosage
Adults
500 mcg to 1500 mcg orally once daily, or as directed by physician. For severe cases, higher doses or injections may be prescribed.
Elderly
No specific dose adjustment required, but monitor for absorption issues and underlying conditions that might affect Vitamin B12 levels.
Renal_impairment
No dose adjustment typically needed as Methylcobalamin is primarily water-soluble and excreted via urine without significant renal processing.
How to Take
Oral tablet should be taken with or without food. Injections are administered intramuscularly.
Mechanism of Action
Methylcobalamin acts as a coenzyme in metabolic processes, including nucleic acid synthesis, red blood cell formation, and the maintenance of the myelin sheath that covers nerve fibers. It helps regenerate damaged nerves and supports nerve cell metabolism.
Pharmacokinetics
Onset
Several days to weeks for noticeable clinical effects, especially for neuropathic symptoms.
Excretion
Primarily excreted via urine, with some enterohepatic recirculation.
Half life
Approximately 6 days in plasma, but storage in the liver leads to a much longer overall duration of action and effects.
Absorption
Well absorbed orally; absorption is improved with intrinsic factor and can also occur via passive diffusion.
Metabolism
Converted to active coenzymes in the body; primarily metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Methylcobalamin or any component of the formulation
- •Leber's disease or tobacco amblyopia (due to risk of optic nerve atrophy)
Drug Interactions
Metformin
Long-term use of metformin can lead to Vitamin B12 deficiency.
Colchicine
May impair the absorption of Vitamin B12.
Chloramphenicol
May decrease the hematologic response to Methylcobalamin.
Proton pump inhibitors
May reduce the absorption of oral Vitamin B12 by altering gastric pH.
H2-receptor antagonists
Similar to PPIs, these can reduce B12 absorption.
Storage
Store in a cool, dry place, away from direct light and moisture. Keep below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Methylcobalamin is a water-soluble vitamin, and overdose is unlikely to cause toxicity. High doses are generally well tolerated with minimal adverse effects. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation when medically indicated. Vitamin B12 is essential for fetal development and is present in breast milk. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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