Medroxy
Generic Name
Medroxyprogesterone Acetate
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| medroxy 10 mg tablet | ৳ 10.07 | ৳ 151.05 |
Description
Overview of the medicine
Medroxyprogesterone Acetate is a synthetic progestogen used for various gynecological conditions, contraception, and as part of hormone replacement therapy. It mimics the natural hormone progesterone.
Uses & Indications
Dosage
Adults
Secondary amenorrhea: 5-10 mg daily for 5-10 days. Abnormal uterine bleeding: 5-10 mg daily for 5-10 days, starting on day 16 or 21 of cycle. Endometriosis: 10 mg 3 times daily for 90 consecutive days. Adjunct to estrogen therapy: 5-10 mg daily for 10-14 days of a 28-day cycle.
Elderly
No specific dose adjustment generally needed, but use with caution due to potential comorbidities.
Renal_impairment
No specific dose adjustment recommendations are available; use with caution.
How to Take
Orally, with or without food. Take at the same time each day.
Mechanism of Action
Medroxyprogesterone Acetate acts primarily on the endometrium, converting it from a proliferative to a secretory state. It inhibits gonadotropin secretion, thereby preventing follicular maturation and ovulation. It also thickens cervical mucus, making it less permeable to sperm.
Pharmacokinetics
Onset
Variable, depending on indication. For withdrawal bleeding, usually within 3-7 days after discontinuation.
Excretion
Primarily via urine and feces as metabolites.
Half life
Approximately 12-17 hours (for oral).
Absorption
Well absorbed orally. Peak plasma concentrations are reached in 2-4 hours.
Metabolism
Primarily hepatic, extensively metabolized via hydroxylation and conjugation.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed vaginal bleeding
- Severe liver disease
- Known or suspected breast cancer or other progestogen-sensitive cancers
- Thromboembolic disorders (current or history of)
Drug Interactions
Rifampicin
May decrease the effectiveness of Medroxyprogesterone Acetate due to increased metabolism.
Grapefruit juice
May increase Medroxyprogesterone Acetate levels.
Aminoglutethimide
May significantly decrease Medroxyprogesterone Acetate plasma levels.
Phenytoin, Carbamazepine
May decrease Medroxyprogesterone Acetate plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms are generally not life-threatening and may include nausea, vomiting, breast tenderness, and vaginal bleeding. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not for use in pregnancy. Small amounts may pass into breast milk; use with caution during lactation and only if clearly needed after consulting a doctor.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed vaginal bleeding
- Severe liver disease
- Known or suspected breast cancer or other progestogen-sensitive cancers
- Thromboembolic disorders (current or history of)
Drug Interactions
Rifampicin
May decrease the effectiveness of Medroxyprogesterone Acetate due to increased metabolism.
Grapefruit juice
May increase Medroxyprogesterone Acetate levels.
Aminoglutethimide
May significantly decrease Medroxyprogesterone Acetate plasma levels.
Phenytoin, Carbamazepine
May decrease Medroxyprogesterone Acetate plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms are generally not life-threatening and may include nausea, vomiting, breast tenderness, and vaginal bleeding. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not for use in pregnancy. Small amounts may pass into breast milk; use with caution during lactation and only if clearly needed after consulting a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Medroxyprogesterone Acetate for its approved indications.
Lab Monitoring
- Annual gynecological exam, including breast exam and Pap smear
- Blood pressure monitoring
- Lipid profile (for long-term use)
Doctor Notes
- Counsel patients on potential for irregular bleeding, especially during the initial months of therapy.
- Assess for risk factors for thromboembolic events before initiating and during therapy.
- Consider bone mineral density monitoring in long-term users, particularly adolescents and those with other risk factors for osteoporosis.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medicines, supplements, and herbal products you are taking.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking, especially if taking this medicine for contraception or HRT, as it increases the risk of serious cardiovascular events.
- Limit alcohol consumption.
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Global Brand Names
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