Medroxy
Generic Name
Medroxyprogesterone Acetate
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| medroxy 5 mg tablet | ৳ 5.40 | ৳ 81.00 |
Description
Overview of the medicine
Medroxyprogesterone Acetate is a synthetic progestin used for various gynecological conditions and as a component of hormone replacement therapy.
Uses & Indications
Dosage
Adults
Secondary Amenorrhea: 5-10 mg daily for 5-10 days. Abnormal Uterine Bleeding: 5-10 mg daily for 5-10 days. Endometriosis: 10 mg 3 times daily for 90 consecutive days. Hormone Replacement Therapy: 2.5-5 mg daily continuously or 5-10 mg for 10-14 days monthly.
Elderly
Generally similar to adult dosage, but caution with concomitant diseases and polypharmacy.
Renal_impairment
No specific dosage adjustment is generally needed for renal impairment, but caution should be exercised.
How to Take
Take orally with or without food, as directed by a healthcare professional. It is usually taken at the same time each day.
Mechanism of Action
Medroxyprogesterone Acetate primarily acts by binding to progesterone receptors, leading to changes in the endometrium (thinning), inhibition of gonadotropin secretion, and prevention of ovulation. It can also thicken cervical mucus.
Pharmacokinetics
Onset
Varies by indication, generally within hours to days for therapeutic effects.
Excretion
Mainly excreted in urine as glucuronide conjugates, with some fecal excretion.
Half life
Approximately 12-17 hours (oral).
Absorption
Well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Extensively metabolized in the liver via hydroxylation and conjugation.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed abnormal vaginal bleeding
- Known or suspected breast cancer or other progestin-sensitive cancer
- Active thrombophlebitis, or history of thromboembolic disorders
- Severe liver dysfunction or disease
Drug Interactions
Warfarin
May alter the effects of warfarin; careful monitoring of INR is advised.
Aminoglutethimide
May significantly decrease the bioavailability of medroxyprogesterone.
CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole)
May increase medroxyprogesterone levels.
CYP3A4 inducers (e.g., Rifampin, Phenytoin, Carbamazepine, St. John's Wort)
May decrease medroxyprogesterone levels, potentially reducing efficacy.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, and abnormal uterine bleeding. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy. Use with caution in breastfeeding mothers; small amounts may pass into breast milk.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed abnormal vaginal bleeding
- Known or suspected breast cancer or other progestin-sensitive cancer
- Active thrombophlebitis, or history of thromboembolic disorders
- Severe liver dysfunction or disease
Drug Interactions
Warfarin
May alter the effects of warfarin; careful monitoring of INR is advised.
Aminoglutethimide
May significantly decrease the bioavailability of medroxyprogesterone.
CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole)
May increase medroxyprogesterone levels.
CYP3A4 inducers (e.g., Rifampin, Phenytoin, Carbamazepine, St. John's Wort)
May decrease medroxyprogesterone levels, potentially reducing efficacy.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, and abnormal uterine bleeding. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy. Use with caution in breastfeeding mothers; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various indications, including hormone replacement therapy and menstrual disorders. Ongoing research focuses on long-term safety profiles.
Lab Monitoring
- Periodic physical examination including blood pressure, breasts, abdomen, and pelvic organs.
- Baseline and periodic mammograms for women on HRT.
- Monitoring of lipid profiles and liver function tests, especially with long-term use.
- Blood glucose levels (especially in diabetic patients).
Doctor Notes
- Carefully assess patient history, especially regarding thromboembolic events, breast cancer, and liver disease before initiating therapy.
- Regular monitoring and patient education on potential risks and benefits are crucial.
- For HRT, use the lowest effective dose for the shortest duration consistent with treatment goals.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Report any unusual vaginal bleeding or spotting to your doctor immediately.
- Inform your doctor about any history of blood clots, breast cancer, or liver disease.
- Do not use if you are pregnant or suspect you might be pregnant.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking, especially if you are on hormone replacement therapy, due to increased risk of cardiovascular events.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Medroxy Brand
Other medicines available under the same brand name
