Memanto
Generic Name
Memantine 10 mg Tablet
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| memanto 10 mg tablet | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
Memanto 10 mg Tablet contains Memantine, a medicine used to treat moderate to severe Alzheimer's disease. It helps to improve memory, awareness, and the ability to perform daily functions by affecting certain brain chemicals.
Uses & Indications
Dosage
Adults
Initially 5 mg once daily, increasing gradually by 5 mg increments at weekly intervals to a target maintenance dose of 20 mg once daily. Max dose 20 mg/day.
Elderly
No dosage adjustment needed based on age. Follow adult dosage. However, monitor renal function.
Renal_impairment
Moderate (Creatinine Clearance 30-49 mL/min): Max dose 10 mg once daily. Severe (Creatinine Clearance 5-29 mL/min): Max dose 5 mg once daily.
How to Take
Memanto tablets should be taken orally, once daily, with or without food. It is recommended to administer at approximately the same time each day for consistency.
Mechanism of Action
Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It works by blocking the effects of excessive glutamate, a brain chemical that, in high amounts, may contribute to neuronal dysfunction and cognitive decline in Alzheimer's disease.
Pharmacokinetics
Onset
Clinical effects may take several weeks to become apparent. Maximum benefit usually observed after consistent use for several months.
Excretion
Primarily via the kidneys, largely as unchanged drug (48%) and metabolites. Renal excretion accounts for approximately 75% of total clearance.
Half life
Approximately 60 to 80 hours.
Absorption
Well absorbed orally, with absolute bioavailability of approximately 100%. Peak plasma concentration is reached within 3 to 7 hours.
Metabolism
Memantine undergoes partial hepatic metabolism, primarily by N-glucuronidation and N-demethylation, resulting in three polar metabolites. However, a significant portion is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to memantine hydrochloride or any of the excipients in the tablet.
Drug Interactions
Hydrochlorothiazide
Memantine may decrease the clearance of hydrochlorothiazide, potentially leading to increased levels of the diuretic.
N-methyl-D-aspartate (NMDA) antagonists
Concomitant administration with other NMDA-receptor antagonists (amantadine, ketamine, dextromethorphan) should be avoided due to the risk of potentiation of central nervous system effects.
Drugs excreted by renal tubular secretion
Cimetidine, ranitidine, quinidine, and nicotine are cleared by the same renal cation transport system as memantine. Co-administration could theoretically alter the plasma levels of either or both drugs.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, somnolence, stupor, and seizures. Treatment involves general supportive measures and symptomatic treatment, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Memanto should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether memantine is excreted in human breast milk, therefore caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to memantine hydrochloride or any of the excipients in the tablet.
Drug Interactions
Hydrochlorothiazide
Memantine may decrease the clearance of hydrochlorothiazide, potentially leading to increased levels of the diuretic.
N-methyl-D-aspartate (NMDA) antagonists
Concomitant administration with other NMDA-receptor antagonists (amantadine, ketamine, dextromethorphan) should be avoided due to the risk of potentiation of central nervous system effects.
Drugs excreted by renal tubular secretion
Cimetidine, ranitidine, quinidine, and nicotine are cleared by the same renal cation transport system as memantine. Co-administration could theoretically alter the plasma levels of either or both drugs.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, somnolence, stupor, and seizures. Treatment involves general supportive measures and symptomatic treatment, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Memanto should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether memantine is excreted in human breast milk, therefore caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Memantine has been extensively studied in various clinical trials, demonstrating its efficacy and safety in patients with moderate to severe Alzheimer's disease. Trials have shown improvements in cognitive function, daily activities, and global clinical assessment scores.
Lab Monitoring
- Routine lab monitoring is not generally required. However, renal function should be assessed periodically, especially in patients with impaired kidney function or during dose titration.
Doctor Notes
- Consider memantine for patients with moderate to severe Alzheimer's disease who cannot tolerate or respond adequately to cholinesterase inhibitors, or in combination therapy.
- Initiate treatment at a low dose and titrate slowly to the target dose to minimize gastrointestinal and CNS side effects.
- Monitor renal function, especially in elderly patients and those with pre-existing renal impairment.
Patient Guidelines
- Take Memanto exactly as prescribed by your doctor.
- Do not stop taking Memanto suddenly without consulting your doctor, as this may worsen your condition.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If a dose of Memanto is missed, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Memanto may cause dizziness, confusion, or visual disturbances. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that memantine therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy diet and engage in regular physical activity suitable for your condition.
- Engage in mentally stimulating activities like reading, puzzles, or social interactions to support cognitive health.
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International brand names for this medicine. Click a brand to search for detailed information.
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