Memanto
Generic Name
Memantine Hydrochloride
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| memanto 5 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Memantine is a medication used to treat moderate to severe Alzheimer's disease. It works by affecting certain natural substances in the brain that are involved in memory and learning, potentially improving symptoms such as confusion and memory loss.
Uses & Indications
Dosage
Adults
Initial dose of 5 mg once daily, gradually increasing by 5 mg increments weekly to a target maintenance dose of 10 mg twice daily (20 mg/day).
Elderly
No specific dosage adjustment needed based on age alone, but monitor renal function carefully.
Renal_impairment
For moderate renal impairment (CrCl 30-49 mL/min), maximum recommended dose is 10 mg/day. For severe renal impairment (CrCl 5-29 mL/min), maximum recommended dose is 5 mg/day.
How to Take
Memantine tablets should be taken orally once a day with or without food. It is recommended to take the medicine at the same time each day.
Mechanism of Action
Memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist. It blocks the persistent overstimulation of NMDA receptors by glutamate, which is believed to contribute to neuronal dysfunction and cognitive impairment in Alzheimer's disease.
Pharmacokinetics
Onset
Clinical effects may be noticeable within weeks, but full therapeutic benefits may take longer.
Excretion
Primarily renal excretion (urine).
Half life
Approximately 60 to 80 hours.
Absorption
Rapidly and completely absorbed orally. Peak plasma concentrations are achieved within 3 to 7 hours. Absolute bioavailability is approximately 100%.
Metabolism
Memantine undergoes limited hepatic metabolism. Approximately 48% is excreted unchanged, while metabolites are formed via N-demethylation and conjugation.
Side Effects
Contraindications
- Hypersensitivity to memantine or any excipient of the tablet.
Drug Interactions
Other NMDA antagonists (e.g., amantadine, ketamine, dextromethorphan)
Co-administration should be avoided due to potential for additive pharmacodynamic effects.
Drugs that increase urine pH (e.g., carbonic anhydrase inhibitors, sodium bicarbonate)
Can decrease memantine renal clearance, leading to increased plasma levels and potential toxicity.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, somnolence, stupor, vertigo, and increased excitability. Treatment should be symptomatic and supportive, including gastric lavage if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Memantine is excreted in human milk, so caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to memantine or any excipient of the tablet.
Drug Interactions
Other NMDA antagonists (e.g., amantadine, ketamine, dextromethorphan)
Co-administration should be avoided due to potential for additive pharmacodynamic effects.
Drugs that increase urine pH (e.g., carbonic anhydrase inhibitors, sodium bicarbonate)
Can decrease memantine renal clearance, leading to increased plasma levels and potential toxicity.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, somnolence, stupor, vertigo, and increased excitability. Treatment should be symptomatic and supportive, including gastric lavage if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Memantine is excreted in human milk, so caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA, EMA, DGDA
Patent Status
Patent expired, generics available
Clinical Trials
Memantine has been extensively studied in various clinical trials, demonstrating its efficacy and safety in improving cognitive function and global clinical status in patients with moderate to severe Alzheimer's disease. Studies have shown improvements in ADAS-Cog and CIBIC-plus scores.
Lab Monitoring
- Regular monitoring of renal function (e.g., serum creatinine, creatinine clearance) is recommended, especially in patients with pre-existing renal impairment.
Doctor Notes
- Gradual titration is crucial to minimize side effects.
- Assess renal function before initiating and periodically during treatment.
- Can be used in combination with cholinesterase inhibitors.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about any new or worsening symptoms or side effects.
- Ensure adequate hydration.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.
Driving Precautions
Memantine may cause dizziness, confusion, or drowsiness. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain a healthy diet and engage in regular physical activity.
- Participate in cognitive and social activities to help stimulate the brain.
- Ensure a safe home environment to minimize fall risks.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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