Mepogest
Generic Name
Medroxyprogesterone Acetate
Manufacturer
Renata Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mepogest 5 mg tablet | ৳ 5.50 | ৳ 55.00 |
Description
Overview of the medicine
Medroxyprogesterone Acetate is a synthetic progestogen used to treat various gynecological conditions such as dysfunctional uterine bleeding, secondary amenorrhea, and endometriosis. It is also a component of hormone replacement therapy.
Uses & Indications
Dosage
Adults
Dysfunctional Uterine Bleeding: 5-10 mg daily for 5-10 days, starting on the 16th or 21st day of the menstrual cycle. Secondary Amenorrhea: 5-10 mg daily for 5-10 days. Endometriosis: 10 mg three times daily for 90 consecutive days. Doses vary for other indications and should be individualized by a physician.
Elderly
No specific dosage adjustment is generally required for elderly patients unless there is significant hepatic or renal impairment. Use with caution.
Renal_impairment
No specific dosage adjustment is generally recommended for renal impairment, but caution is advised in severe cases.
How to Take
Take orally with or without food. It is recommended to take the tablet at the same time each day to maintain consistent hormone levels.
Mechanism of Action
Medroxyprogesterone Acetate acts on the endometrium, converting it from a proliferative to a secretory phase. It also inhibits gonadotropin secretion from the pituitary gland, thereby preventing ovulation.
Pharmacokinetics
Onset
Therapeutic effects typically seen within hours to days depending on the indication.
Excretion
Mainly excreted in urine as glucuronide conjugates, with some fecal excretion.
Half life
Approximately 12 to 17 hours (for oral administration).
Absorption
Well absorbed orally, with peak plasma concentrations occurring 2-4 hours after administration.
Metabolism
Extensively metabolized in the liver via hydroxylation and conjugation, primarily by CYP3A4 enzymes.
Side Effects
Contraindications
- •Known or suspected pregnancy
- •Undiagnosed abnormal vaginal bleeding
- •Active thrombophlebitis, or current or past history of thromboembolic disorders
- •Severe liver dysfunction or disease
- •Known or suspected malignancy of the breast or genital organs (unless used for treatment)
- •Hypersensitivity to medroxyprogesterone acetate or any component of the tablet
Drug Interactions
Aminoglutethimide
May decrease the bioavailability of medroxyprogesterone acetate.
CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole)
May increase plasma concentrations of medroxyprogesterone acetate.
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)
May reduce plasma concentrations of medroxyprogesterone acetate.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is generally well-tolerated with no serious acute toxicity reported. Management should be symptomatic and supportive.
Pregnancy & Lactation
Medroxyprogesterone Acetate is contraindicated during pregnancy. It is not recommended during lactation as small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
