Meroclav
Generic Name
Cefixime + Clavulanic Acid 125 mg Suspension
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| meroclav 125 mg suspension | ৳ 250.00 | N/A |
Description
Overview of the medicine
Meroclav 125 mg Suspension is an antibiotic medication used to treat a wide range of bacterial infections. It contains Cefixime, a third-generation cephalosporin, and Clavulanic Acid, a beta-lactamase inhibitor, which protects Cefixime from degradation by bacterial enzymes.
Uses & Indications
Dosage
Adults
Not typically used in adults in this suspension form. Adult formulations (e.g., tablets) are available with different strengths and dosages.
Elderly
No specific dosage adjustment needed based on age alone, but renal function should be assessed. If using adult formulations, adjust according to renal impairment.
Children
Cefixime 8 mg/kg/day administered as a single dose or in two divided doses. For Meroclav 125 mg/5 ml suspension, dosage will depend on the child's weight and age, typically 5ml once or twice daily for specific indications and age groups. Follow doctor's instructions.
Renal_impairment
Dosage reduction is recommended for patients with severe renal impairment (creatinine clearance < 30 ml/min). Consult a physician for specific adjustments.
How to Take
Administer orally. Shake the bottle well before each use. Can be taken with or without food. Use the provided measuring device for accurate dosing. Complete the full prescribed course of treatment.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death. Clavulanic Acid irreversibly binds to and inhibits beta-lactamase enzymes produced by bacteria, thereby protecting Cefixime from hydrolysis and extending its antibacterial spectrum.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours for Cefixime and about 1 hour for Clavulanic Acid after oral administration.
Excretion
Cefixime is primarily excreted unchanged in the urine (about 50%). Clavulanic Acid is primarily excreted in the urine, partly as metabolites.
Half life
Cefixime: 3-4 hours; Clavulanic Acid: approximately 1 hour.
Absorption
Cefixime is approximately 40-50% absorbed orally. Clavulanic Acid is well absorbed orally.
Metabolism
Cefixime undergoes limited metabolism. Clavulanic Acid is extensively metabolized to inactive compounds.
Side Effects
Contraindications
- Hypersensitivity to Cefixime, Clavulanic Acid, other cephalosporins, penicillins, or any component of the formulation.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any beta-lactam antibiotic.
Drug Interactions
Warfarin
Concurrent use may increase the anticoagulant effect of warfarin, requiring monitoring of INR and potential dose adjustment.
Nifedipine
May increase Cefixime concentrations.
Carbamazepine
Concomitant administration may increase carbamazepine levels.
Aminoglycosides
Increased risk of nephrotoxicity when co-administered with other nephrotoxic drugs like aminoglycosides.
Storage
Store dry powder below 30°C, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and not frozen.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be indicated. There is no specific antidote. Hemodialysis or peritoneal dialysis does not remove Cefixime or Clavulanic Acid in significant quantities.
Pregnancy & Lactation
Cefixime and Clavulanic Acid are classified as Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Exercise caution when administering to a nursing mother, as small amounts may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Cefixime, Clavulanic Acid, other cephalosporins, penicillins, or any component of the formulation.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any beta-lactam antibiotic.
Drug Interactions
Warfarin
Concurrent use may increase the anticoagulant effect of warfarin, requiring monitoring of INR and potential dose adjustment.
Nifedipine
May increase Cefixime concentrations.
Carbamazepine
Concomitant administration may increase carbamazepine levels.
Aminoglycosides
Increased risk of nephrotoxicity when co-administered with other nephrotoxic drugs like aminoglycosides.
Storage
Store dry powder below 30°C, protected from light and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and not frozen.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be indicated. There is no specific antidote. Hemodialysis or peritoneal dialysis does not remove Cefixime or Clavulanic Acid in significant quantities.
Pregnancy & Lactation
Cefixime and Clavulanic Acid are classified as Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Exercise caution when administering to a nursing mother, as small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for dry powder. Reconstituted suspension should be used within 7-14 days when stored in a refrigerator.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Both Cefixime and Clavulanic Acid have undergone extensive clinical trials demonstrating their efficacy and safety. Specific combination trials have also been conducted to establish the synergistic benefits in treating various bacterial infections.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
- Complete Blood Count (CBC) for prolonged treatment to monitor for hematologic abnormalities.
Doctor Notes
- Assess renal function, especially in pediatric patients, as Cefixime is primarily renally excreted.
- Counsel patients/caregivers on the importance of completing the full course of therapy to prevent resistance.
- Be vigilant for signs of C. difficile-associated diarrhea (CDAD), which can occur even weeks after discontinuation.
Patient Guidelines
- Complete the entire course of treatment, even if symptoms improve, to prevent the development of antibiotic resistance.
- Shake the suspension well before each use to ensure even distribution of the medicine.
- Do not share this medicine with others, even if they have similar symptoms.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Meroclav 125 mg Suspension may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids, especially if experiencing diarrhea.
- Practice good hygiene to prevent the spread of infection.
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