Meroclav
Generic Name
Amoxicillin 500 mg + Clavulanic Acid 125 mg
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| meroclav 500 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Meroclav 500 mg Tablet is an antibiotic medication combining Amoxicillin, a penicillin-type antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat a wide range of bacterial infections susceptible to this combination.
Uses & Indications
Dosage
Adults
One 500 mg/125 mg tablet every 8 hours, or as directed by physician. For more severe infections, dosage may be increased.
Elderly
Same as adults, but caution with renal impairment; dosage adjustment may be needed.
Renal_impairment
Dosage adjustment required based on creatinine clearance. For CrCl 10-30 mL/min, 500 mg/125 mg every 12 hours; for CrCl <10 mL/min, 500 mg/125 mg every 24 hours.
How to Take
Taken orally at the start of a meal to minimize potential gastrointestinal intolerance. Swallow whole with water.
Mechanism of Action
Amoxicillin acts by inhibiting bacterial cell wall synthesis, leading to bacterial lysis and death. Clavulanic acid inhibits beta-lactamase enzymes produced by some bacteria, which would otherwise inactivate Amoxicillin, thus extending Amoxicillin's antibacterial spectrum.
Pharmacokinetics
Onset
Within 1-2 hours (antibacterial activity)
Excretion
Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion).
Half life
Approximately 1-1.5 hours for both components.
Absorption
Both Amoxicillin and Clavulanic Acid are well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Amoxicillin is minimally metabolized; Clavulanic Acid is extensively metabolized.
Side Effects
Contraindications
- History of hypersensitivity to Amoxicillin, Clavulanic Acid, or any penicillin.
- History of cholestatic jaundice/hepatic dysfunction associated with Amoxicillin/Clavulanic Acid.
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR closely.
Probenecid
Increases and prolongs Amoxicillin blood levels.
Allopurinol
Increased incidence of rash.
Methotrexate
May increase methotrexate toxicity by inhibiting its renal excretion.
Oral Contraceptives
May reduce efficacy of oral contraceptives; consider alternative contraception.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset and fluid/electrolyte imbalance. Treatment is symptomatic and supportive. Hemodialysis may be used to remove the drug from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use with caution and only if clearly needed. Excreted in breast milk, monitor infants for diarrhea, candidiasis, and skin rash.
Side Effects
Contraindications
- History of hypersensitivity to Amoxicillin, Clavulanic Acid, or any penicillin.
- History of cholestatic jaundice/hepatic dysfunction associated with Amoxicillin/Clavulanic Acid.
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR closely.
Probenecid
Increases and prolongs Amoxicillin blood levels.
Allopurinol
Increased incidence of rash.
Methotrexate
May increase methotrexate toxicity by inhibiting its renal excretion.
Oral Contraceptives
May reduce efficacy of oral contraceptives; consider alternative contraception.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset and fluid/electrolyte imbalance. Treatment is symptomatic and supportive. Hemodialysis may be used to remove the drug from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use with caution and only if clearly needed. Excreted in breast milk, monitor infants for diarrhea, candidiasis, and skin rash.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities worldwide, including FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for efficacy and safety against various bacterial infections, demonstrating significant success rates.
Lab Monitoring
- Liver function tests (in patients with hepatic dysfunction)
- Renal function tests (in patients with renal impairment)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent recurrence and resistance.
- Counsel patients on potential for gastrointestinal upset and strategies to mitigate (e.g., take with food or milk).
- Advise patients to seek immediate medical attention if signs of a severe allergic reaction (e.g., anaphylaxis, SJS) occur.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Take with food to reduce stomach upset.
- Report any severe diarrhea, rash, or allergic reactions immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
May cause dizziness; advise patients to use caution when driving or operating machinery until they know how the medication affects them.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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