Meroject
Generic Name
Meropenem
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| meroject 1 gm injection | ৳ 1,300.00 | N/A |
Description
Overview of the medicine
Meroject 1 gm Injection contains Meropenem, which is a broad-spectrum carbapenem antibiotic. It is used to treat serious bacterial infections in various parts of the body.
Uses & Indications
Dosage
Adults
Usual dose is 0.5 gm to 2 gm intravenously every 8 hours, depending on the type and severity of infection. For meningitis, 2 gm every 8 hours.
Elderly
Dosage adjustment may be necessary based on renal function. No specific dosage adjustment required solely for age.
Renal_impairment
Dosage should be reduced based on creatinine clearance (CrCl). For CrCl 26-50 mL/min, administer full dose every 12 hours; for CrCl 10-25 mL/min, administer half dose every 12 hours; for CrCl <10 mL/min, administer half dose every 24 hours.
How to Take
Meroject 1 gm Injection should be administered by intravenous infusion over 15 to 30 minutes, or by intravenous bolus injection (500 mg to 1 gm) over 3 to 5 minutes.
Mechanism of Action
Meropenem is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It penetrates the bacterial cell and binds to penicillin-binding proteins (PBPs), leading to inhibition of peptidoglycan synthesis and ultimately bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid (within minutes of IV administration)
Excretion
Approximately 70% of the administered dose is recovered unchanged in the urine within 12 hours. Renal elimination is the primary route.
Half life
Approximately 1 hour (in adults with normal renal function)
Absorption
Rapid and complete absorption after intravenous administration. Peak plasma concentrations are achieved shortly after the end of infusion.
Metabolism
Minimal hepatic metabolism. Primarily hydrolyzed by the ring-opening of the beta-lactam moiety to an inactive metabolite, though it is stable to dehydropeptidase-I.
Side Effects
Contraindications
- Known hypersensitivity to meropenem, any other carbapenem antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Probenecid competes with meropenem for active tubular secretion, leading to increased plasma concentrations and prolonged half-life of meropenem. Co-administration with probenecid is not recommended.
Valproic acid/Divalproex sodium
Carbapenems, including meropenem, may decrease valproic acid plasma concentrations to subtherapeutic levels, leading to loss of seizure control. Concomitant use is generally not recommended.
Storage
Store below 30°C. Protect from light. Do not freeze. Reconstituted solutions should be used immediately or stored according to manufacturer's instructions for a limited time.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but there are no adequate and well-controlled studies in pregnant women. Meropenem is excreted in human milk in very low concentrations. Use during pregnancy and lactation only if clearly needed and the potential benefit justifies the potential risk to the fetus/infant.
Side Effects
Contraindications
- Known hypersensitivity to meropenem, any other carbapenem antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Probenecid competes with meropenem for active tubular secretion, leading to increased plasma concentrations and prolonged half-life of meropenem. Co-administration with probenecid is not recommended.
Valproic acid/Divalproex sodium
Carbapenems, including meropenem, may decrease valproic acid plasma concentrations to subtherapeutic levels, leading to loss of seizure control. Concomitant use is generally not recommended.
Storage
Store below 30°C. Protect from light. Do not freeze. Reconstituted solutions should be used immediately or stored according to manufacturer's instructions for a limited time.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but there are no adequate and well-controlled studies in pregnant women. Meropenem is excreted in human milk in very low concentrations. Use during pregnancy and lactation only if clearly needed and the potential benefit justifies the potential risk to the fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture. Refer to product specific packaging for exact expiry.
Availability
Hospitals, Pharmacies
Approval Status
Approved (e.g., DGDA, FDA)
Patent Status
Off-patent (for generic Meropenem)
WHO Essential Medicine
YesClinical Trials
Meropenem has undergone extensive clinical trials demonstrating its efficacy and safety in various severe bacterial infections across different patient populations, including pediatric and adult patients.
Lab Monitoring
- Renal function (creatinine, BUN)
- Liver function tests (ALT, AST, ALP)
- Complete blood count (CBC)
- Culture and susceptibility testing of causative organisms
Doctor Notes
- Appropriate use of meropenem is crucial to preserve its efficacy and prevent resistance. Reserve for severe infections caused by susceptible organisms where other antibiotics are less suitable.
- Careful monitoring of renal function is essential, especially in elderly and renally impaired patients, to ensure appropriate dose adjustment.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve earlier.
- Report any unusual or severe side effects, especially persistent diarrhea or seizures, to your doctor.
- Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Meropenem may cause dizziness or seizures in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay well-hydrated during treatment.
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