Meroject
Generic Name
Meropenem
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| meroject 500 mg injection | ৳ 700.00 | N/A |
Description
Overview of the medicine
Meropenem is a carbapenem antibiotic used to treat severe bacterial infections in adults and children, including pneumonia, complicated intra-abdominal infections, and meningitis.
Uses & Indications
Dosage
Adults
500 mg to 1 g IV every 8 hours, depending on the type and severity of infection, up to 2 g every 8 hours for certain severe infections.
Elderly
No specific dose adjustment needed based on age alone, but renal function should be closely monitored and dose adjusted if impairment is present.
Renal_impairment
Dose adjustment required based on creatinine clearance (e.g., CrCl 26-50 mL/min: 500 mg every 12 hours; CrCl 10-25 mL/min: 250 mg every 12 hours; CrCl <10 mL/min: 250 mg every 24 hours).
How to Take
Meroject 500 mg injection is for intravenous use only. It can be administered by intravenous infusion over approximately 15 to 30 minutes or as an intravenous bolus over 3 to 5 minutes.
Mechanism of Action
Meropenem exerts its bactericidal activity by inhibiting bacterial cell wall synthesis. It penetrates the bacterial cell wall rapidly and binds to penicillin-binding proteins (PBPs), disrupting peptidoglycan synthesis.
Pharmacokinetics
Onset
Rapid, typically within minutes of IV administration.
Excretion
Mainly renal, with approximately 70% of the administered dose excreted unchanged in the urine within 12 hours.
Half life
Approximately 1 hour in individuals with normal renal function.
Absorption
Rapid and complete after intravenous administration, with peak plasma concentrations achieved shortly after the end of infusion.
Metabolism
Primarily hydrolyzed in the kidney to an inactive open-ring metabolite, with minimal hepatic metabolism.
Side Effects
Contraindications
- Known hypersensitivity to meropenem or any other carbapenem antibiotics.
- Known hypersensitivity to any other beta-lactam antibacterial agents (e.g., penicillins, cephalosporins) due to potential cross-reactivity.
- Patients with a history of severe hypersensitivity reaction to any component of the formulation.
Drug Interactions
Probenecid
Co-administration with probenecid results in increased plasma concentrations and prolonged elimination half-life of meropenem by inhibiting its renal excretion.
Valproic Acid
Concurrent use with meropenem may reduce valproic acid levels below the therapeutic range, leading to loss of seizure control. Co-administration is generally not recommended.
Oral Anticoagulants
Anticoagulant activity may be enhanced when carbapenems are co-administered with warfarin or similar oral anticoagulants.
Storage
Store the unopened vials below 25°C (77°F) and protect from light. Do not freeze. Reconstituted solutions should be used promptly as directed by manufacturer guidelines.
Overdose
In the event of an overdose, symptomatic treatment and supportive measures are recommended. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Meropenem should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk in very low concentrations, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to meropenem or any other carbapenem antibiotics.
- Known hypersensitivity to any other beta-lactam antibacterial agents (e.g., penicillins, cephalosporins) due to potential cross-reactivity.
- Patients with a history of severe hypersensitivity reaction to any component of the formulation.
Drug Interactions
Probenecid
Co-administration with probenecid results in increased plasma concentrations and prolonged elimination half-life of meropenem by inhibiting its renal excretion.
Valproic Acid
Concurrent use with meropenem may reduce valproic acid levels below the therapeutic range, leading to loss of seizure control. Co-administration is generally not recommended.
Oral Anticoagulants
Anticoagulant activity may be enhanced when carbapenems are co-administered with warfarin or similar oral anticoagulants.
Storage
Store the unopened vials below 25°C (77°F) and protect from light. Do not freeze. Reconstituted solutions should be used promptly as directed by manufacturer guidelines.
Overdose
In the event of an overdose, symptomatic treatment and supportive measures are recommended. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Meropenem should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk in very low concentrations, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
The shelf life is typically 2-3 years for the unopened vial. After reconstitution, the solution must be used immediately or stored for a limited time (e.g., 6 hours at 25°C or 24 hours at 2-8°C, depending on diluent and concentration). Refer to specific product labeling.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Meropenem has undergone extensive clinical trials supporting its efficacy and safety across various severe bacterial infections. Ongoing post-marketing surveillance continues to monitor for new information regarding its use, including resistance patterns and rare adverse events.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, creatinine clearance) especially in patients with pre-existing renal impairment.
- Liver function tests (e.g., AST, ALT, bilirubin) periodically during prolonged treatment.
- Complete blood count (CBC) to monitor for hematologic adverse effects.
- Coagulation parameters if co-administered with anticoagulants.
Doctor Notes
- Perform appropriate cultures and susceptibility tests before and during treatment to isolate and identify causative organisms and to determine their susceptibility to meropenem.
- Monitor patients for signs and symptoms of anaphylaxis and other hypersensitivity reactions during administration, particularly in those with a history of sensitivity to beta-lactam antibiotics.
- Adjust dosage in patients with renal impairment based on creatinine clearance to prevent accumulation and potential adverse effects.
Patient Guidelines
- It is crucial to complete the entire prescribed course of Meroject, even if symptoms improve, to prevent the development of antibiotic resistance.
- Report any new or worsening symptoms, especially severe diarrhea, rash, or signs of an allergic reaction, to your healthcare provider immediately.
- Inform your doctor about all other medications, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential drug interactions.
Missed Dose Advice
If a dose of Meroject is missed, it should be administered as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Meropenem may cause dizziness, confusion, or seizures. Patients should be advised to exercise caution when driving or operating machinery until they know how Meroject affects them.
Lifestyle Advice
- Maintain good personal hygiene to minimize the risk of spreading or acquiring further infections.
- Stay well-hydrated throughout the treatment period.
- Avoid alcohol during treatment, as it may exacerbate side effects like nausea or dizziness (though specific interaction with meropenem is minimal).
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