Mesagut
Generic Name
Mesalamine
Manufacturer
PharmaCo Bangladesh
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mesagut 400 mg tablet | ৳ 7.60 | ৳ 76.00 |
Description
Overview of the medicine
Mesalamine is an anti-inflammatory drug used to treat inflammatory bowel diseases like ulcerative colitis and Crohn's disease.
Uses & Indications
Dosage
Adults
Oral: 2-4 g daily in divided doses. Rectal: 1 g once daily (suppository/enema).
Elderly
No specific dose adjustment, but monitor renal function.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe impairment.
How to Take
Oral tablets/capsules should be taken with or without food as directed. Rectal forms are for local administration.
Mechanism of Action
Exerts topical anti-inflammatory effect in the colon by inhibiting prostaglandin and leukotriene synthesis.
Pharmacokinetics
Onset
Days to weeks for therapeutic effect.
Excretion
Mainly via feces (unabsorbed drug) and urine (metabolite).
Half life
Approximately 0.5 to 1.5 hours (for the parent drug), 5-10 hours (for metabolite N-acetyl-5-aminosalicylic acid).
Absorption
Low systemic absorption, acts locally in the bowel.
Metabolism
Primarily acetylated in the liver and gut wall to N-acetyl-5-aminosalicylic acid.
Side Effects
Contraindications
- •Hypersensitivity to mesalamine or salicylates
- •Severe renal or hepatic impairment
Drug Interactions
NSAIDs
May increase risk of renal toxicity.
Lactulose
May impair mesalamine release from delayed-release formulations.
Azathioprine/Mercaptopurine
Increased risk of myelosuppression.
Storage
Store below 30°C, away from moisture and light.
Overdose
Symptoms include nausea, vomiting, abdominal pain, headache. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use with caution during pregnancy, consult a doctor. Excreted in breast milk, monitor infant for diarrhea.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic, off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
